ESTABLISHING PREDICTORS OF SELF INJURIOUS BEHAVIOR IN RHESUS MONKEYS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们之前已经建立了一种SIB的动物模型，在该模型中，患有这种疾病的猴子也表现出应激反应系统的钝化，阿片系统的失调，并与5-羟色胺转运体基因(5HTTLPR)和单胺氧化酶A启动子(MAOA-LPR)的多态性有关。由于这些研究都是回溯性的，我们不知道这些不同的因素是否在SIB的发生中起因果作用或代表后果。这个项目将调查SIB和刻板行为的预测因素，在这些异常行为表现出来之前。这将通过对一群雄性猴子进行一项独特的、大规模的纵向研究来实现，在该研究中，我们将对咬合率和刻板行为进行行为评估，收集头发和血液样本进行皮质醇和其他分析，并寻找可以预测以后SIB或刻板行为发展的多态基因变异。这些综合征的生物标志物的测定将用于群体筛查和实施新的预防策略。阐明SIB的新生物标志物也将对我们理解人类临床人群中的这种疾病具有重要意义。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We have previously developed an animal model of SIB in which monkeys with this disorder also show a blunting of the stress response system, dysregulation of the opioid system, and associations with polymorphisms of the serotonin transporter gene (5HTTLPR) and the monoamine oxidase A promoter (MAOA-LPR). Because these studies have been retrospective, we do not know whether these various factors play a causal role or represent consequences of developing SIB. This project will investigate predictors of SIB and stereotypic behavior before these abnormal behaviors have become manifested. This will be accomplished by means of a unique, large-scale longitudinal study of a cohort of male monkeys in which we will conduct behavioral assessments of biting rates and stereotypic behavior, collect hair and blood samples for cortisol and other assays, and search for polymorphic gene variants that are predictive of later SIB or stereotypy development. The determination of biomarkers for these syndromes will be used for colony screening and the imposition of new prevention strategies. Elucidation of novel biomarkers of SIB will also have significant implications for our understanding of this disorder in human clinical populations.