ESTABLISHING PREDICTORS OF SELF INJURIOUS BEHAVIOR IN RHESUS MONKEYS

建立恒河猴自残行为的预测因子

• 批准号: 7562081
• 负责人: MARSHA L DAVENPORT
• 金额: $ 0.54万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7562081
• 关键词: Animal Model; Behavior; Behavior assessment; Biological Assay; Biological Markers; Bite; Blood specimen; Clinical; Computer Retrieval of Information on Scientific Projects Database; Development; Disease; Funding; Genes; Genetic Polymorphism; Genetic Variation; Grant; Hair; Human; Hydrocortisone; Institution; Longitudinal Studies; Macaca mulatta; Monkeys; Monoamine Oxidase A; Opioid; Play; Population; Prevention strategy; Rate; Research; Research Personnel; Resources; Role; Screening procedure; Self-Injurious Behavior; Source; Syndrome; System; United States National Institutes of Health; biological adaptation to stress; cohort; male; novel; promoter; serotonin transporter; stereotypy

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We have previously developed an animal model of SIB in which monkeys with this disorder also show a blunting of the stress response system, dysregulation of the opioid system, and associations with polymorphisms of the serotonin transporter gene (5HTTLPR) and the monoamine oxidase A promoter (MAOA-LPR). Because these studies have been retrospective, we do not know whether these various factors play a causal role or represent consequences of developing SIB. This project will investigate predictors of SIB and stereotypic behavior before these abnormal behaviors have become manifested. This will be accomplished by means of a unique, large-scale longitudinal study of a cohort of male monkeys in which we will conduct behavioral assessments of biting rates and stereotypic behavior, collect hair and blood samples for cortisol and other assays, and search for polymorphic gene variants that are predictive of later SIB or stereotypy development. The determination of biomarkers for these syndromes will be used for colony screening and the imposition of new prevention strategies. Elucidation of novel biomarkers of SIB will also have significant implications for our understanding of this disorder in human clinical populations.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 我们之前开发了一种 SIB 动物模型，患有这种疾病的猴子也表现出应激反应系统迟钝、阿片类药物系统失调，以及与血清素转运蛋白基因 (5HTTLPR) 和单胺氧化酶 A 启动子 (MAOA-LPR) 多态性的相关性。 由于这些研究是回顾性的，我们不知道这些不同的因素是否在 SIB 的发生中发挥因果作用或代表其后果。 该项目将在这些异常行为显现之前研究 SIB 和刻板行为的预测因素。 这将通过对一群雄性猴子进行独特的大规模纵向研究来实现，其中我们将对咬合率和刻板行为进行行为评估，收集毛发和血液样本进行皮质醇和其他检测，并寻找可预测后来 SIB 或刻板行为发展的多态性基因变异。 这些综合征的生物标志物的测定将用于菌落筛查和实施新的预防策略。 SIB 的新型生物标志物的阐明也将对我们了解人类临床人群中的这种疾病产生重大影响。