ESTABLISHING PREDICTORS OF SELF INJURIOUS BEHAVIOR IN RHESUS MONKEYS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们以前已经开发了一种动物模型的SIB中，这种疾病的猴子也表现出钝化的应激反应系统，阿片类药物系统的失调，并与多态性的5-羟色胺转运蛋白基因（5 HTTLPR）和单胺氧化酶A启动子（MAOA-LPR）。 由于这些研究是回顾性的，我们不知道这些不同的因素是否发挥因果作用或代表发展SIB的后果。 这个项目将调查SIB和刻板行为的预测因素，在这些异常行为表现出来之前。 这将通过对一组雄性猴子进行独特的大规模纵向研究来实现，在该研究中，我们将对叮咬率和刻板行为进行行为评估，收集毛发和血液样本进行皮质醇和其他测定，并寻找预测后期SIB或刻板发展的多态性基因变体。 这些综合征的生物标志物的确定将用于群体筛查和实施新的预防策略。阐明SIB的新生物标志物也将对我们理解人类临床人群中的这种疾病具有重要意义。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We have previously developed an animal model of SIB in which monkeys with this disorder also show a blunting of the stress response system, dysregulation of the opioid system, and associations with polymorphisms of the serotonin transporter gene (5HTTLPR) and the monoamine oxidase A promoter (MAOA-LPR). Because these studies have been retrospective, we do not know whether these various factors play a causal role or represent consequences of developing SIB. This project will investigate predictors of SIB and stereotypic behavior before these abnormal behaviors have become manifested. This will be accomplished by means of a unique, large-scale longitudinal study of a cohort of male monkeys in which we will conduct behavioral assessments of biting rates and stereotypic behavior, collect hair and blood samples for cortisol and other assays, and search for polymorphic gene variants that are predictive of later SIB or stereotypy development. The determination of biomarkers for these syndromes will be used for colony screening and the imposition of new prevention strategies. Elucidation of novel biomarkers of SIB will also have significant implications for our understanding of this disorder in human clinical populations.