EFFECT OF EARLY GROWTH HORMONE TREATMENT ON LONG-TERM SKELETAL MATURATION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这是一项在参加研究GDFG的Turner综合征受试者中进行的半观察性扩展研究。 GDGH研究的主要目的是评估两年儿童早期GH治疗对接近最终身高的影响。 此外，该研究旨在描述早期GH治疗对中耳和听力功能以及认知和行为发育的长期影响。 由于许多受试者自研究GDFG中止后接受了GH治疗，因此我们预计研究GDGH中两组的治疗方案相似，但GDFG期间的治疗除外。 这项扩展研究将为获得早期GH治疗对特纳综合征患者接近最终身高和健康结局的其他一些重要方面的影响的长期数据提供独特的机会。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a semi-observational extension study of subjects with Turner syndrome who participated in study GDFG. The primary aim of study GDGH is to evaluate the effect of two years of early childhood GH treatment on near-final height. Furthermore, the study seeks to describe long-term effects of early GH treatment on middle ear and hearing function, and on coginitive and behavioral development. Because many subjects have received GH treatment since discontinuation from study GDFG, we expect the treatment regimen for the two groups in study GDGH to be similar, aside from their treatment during GDFG. This extension study will allow for the unique opportunity to obtain long-term data on the effect of early GH treatment on near-final height and a number of other important aspects of health outcome in individuals with Turner syndrome.