EFFECT OF EARLY GROWTH HORMONE TREATMENT ON LONG-TERM SKELETAL MATURATION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这是一项参与GDFG研究的Turner综合征受试者的半观察性延伸研究。研究GDGH的主要目的是评估两年的儿童早期GH治疗对接近终末身高的影响。 此外，该研究试图描述早期生长激素治疗对中耳和听力功能的长期影响，以及对认知和行为发育的影响。由于许多受试者在停止GDFG研究后接受了GH治疗，我们预计GDGH研究中两组患者的治疗方案相似，除了他们在GDFG期间的治疗外。这项扩展研究将提供一个独特的机会，获得有关早期生长激素治疗对特纳综合征患者接近最终身高的影响以及一些其他重要的健康结果方面的长期数据。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a semi-observational extension study of subjects with Turner syndrome who participated in study GDFG. The primary aim of study GDGH is to evaluate the effect of two years of early childhood GH treatment on near-final height. Furthermore, the study seeks to describe long-term effects of early GH treatment on middle ear and hearing function, and on coginitive and behavioral development. Because many subjects have received GH treatment since discontinuation from study GDFG, we expect the treatment regimen for the two groups in study GDGH to be similar, aside from their treatment during GDFG. This extension study will allow for the unique opportunity to obtain long-term data on the effect of early GH treatment on near-final height and a number of other important aspects of health outcome in individuals with Turner syndrome.