Bench-to-Bedside: Identification of Predictive Biomarkers of Asthma Exacerbation

从实验室到临床：哮喘恶化预测生物标志物的鉴定

• 批准号: 7696967
• 负责人: RICHARD E ROTHMAN
• 金额: $ 5万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7696967
• 关键词: Address; Affect; Asthma; Award; Biological Markers; Clinical; Clinical Investigator; Clinical Management; Clinical Protocols; Clinical Research; Conceptions; Detection; Development; Devices; Diagnosis; Diagnostic; Disease; Event; Exhalation; Extramural Activities; Goals; Infectious Diseases Research; Intramural Research; Invasive; Mass Spectrum Analysis; Methods; Minority; Morbidity - disease rate; Patients; Physics; Population; Program Research Project Grants; Public Health; Refractory; Research Personnel; Respiratory Tract Infections; Risk; Scientist; United States National Institutes of Health; Universities; Woman; abstracting; airway inflammation; asthmatic patient; bench to bedside; biodefense; disorder control; health disparity; mortality; novel; programs

Abstract: Asthma is a major public health problem that is associated with significant morbidity and mortality. Patients at high-risk for asthma decompensations include those with severe asthma that is refractory to therapy, as well as patients with poorly controlled disease due to inadequate treatment. We believe that the development of a non-invasive method for the detection of asthma-specific biomarkers that correlate with exacerbations will advance clinical management. Furthermore, since a disproportionate burden of asthma-related morbidity affects minority populations and women, the identification of clinically useful biomarkers may address a health disparity. Thus, the goal of this bench-to-bedside proposal is to use a novel device to collect exhaled breath condensates from asthmatic patients who are at high-risk for frequent exacerbations and identify disease specific biomarkers of airway inflammation by mass spectroscopy (MALDI-TOF). This will be a collaborative study between investigators in the Division of Intramural Research, NHLBl and extramural Investigators at the Johns Hopkins University, who are developing an Applied Physics Lab detection platform for the diagnosis of respiratory infections. The bench-to-bedside award program facilitated the conception of this collaborative proposal that addresses an important clinical problem and will result in a new clinical protocol at the NIH Clinical Research Center. Dr. Levine will be the Principal Clinical Investigator and Dr. Jackman will be the Principal Basic Scientist. Dr. Rothman is the Principal lnvestigator for Project 6.3 (Universal Diagnostic Platforms for Bioterrorist Events) on a NlAlD Program Project Grant (Al57168-04: The Middle- Atlantic Regional Center of Excellence for Biodefense and Emerging infectious Diseases Research).

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