Bench-to-Bedside: Identification of Predictive Biomarkers of Asthma Exacerbation
Bench-to-Bedside: Identification of Predictive Biomarkers of Asthma Exacerbation
批准号:
7696967
负责人:
RICHARD E ROTHMAN
金额:
$5.0万
依托单位国家:
美国
项目类别:
财政年份:
2007
资助国家:
美国
项目状态:
已结题
起止时间:
2007-03-01 至 2009-02-28
关键词:
AddressAffectAsthmaAwardBiological MarkersClinicalClinical InvestigatorClinical ManagementClinical ProtocolsClinical ResearchConceptionsDetectionDevelopmentDevicesDiagnosisDiagnosticDiseaseEventExhalationExtramural ActivitiesGoalsInfectious Diseases ResearchIntramural ResearchInvasiveMass Spectrum AnalysisMethodsMinorityMorbidity - disease ratePatientsPhysicsPopulationProgram Research Project GrantsPublic HealthRefractoryResearch PersonnelRespiratory Tract InfectionsRiskScientistUnited States National Institutes of HealthUniversitiesWomanabstractingairway inflammationasthmatic patientbench to bedsidebiodefensedisorder controlhealth disparitymortalitynovelprograms
中文摘要
文摘:
英文摘要
Abstract:
Asthma is a major public health problem that is associated with significant morbidity and mortality. Patients at high-risk for asthma decompensations include those with severe asthma that is refractory to therapy, as well as patients with poorly controlled disease due to inadequate treatment. We believe that the development of a non-invasive method for the detection of asthma-specific biomarkers that correlate with exacerbations will advance clinical management. Furthermore, since a disproportionate burden of asthma-related morbidity affects minority populations and women, the identification of clinically useful biomarkers may address a health disparity. Thus, the goal of this bench-to-bedside proposal is to use a novel device to collect exhaled breath condensates from asthmatic patients who are at high-risk for frequent exacerbations and identify disease
specific biomarkers of airway inflammation by mass spectroscopy (MALDI-TOF).
This will be a collaborative study between investigators in the Division of Intramural Research, NHLBl and extramural Investigators at the Johns Hopkins University, who are developing an Applied Physics Lab detection platform for the diagnosis of respiratory infections. The bench-to-bedside award program facilitated the conception of this collaborative proposal that addresses an important clinical problem and will result in a new clinical protocol at the NIH Clinical Research Center. Dr. Levine will be the Principal Clinical Investigator and Dr. Jackman will be the Principal Basic Scientist. Dr. Rothman is the Principal lnvestigator for Project 6.3 (Universal Diagnostic Platforms for
Bioterrorist Events) on a NlAlD Program Project Grant (Al57168-04: The Middle-
Atlantic Regional Center of Excellence for Biodefense and Emerging infectious
Diseases Research).
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资助金额:$36.31万
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负责人:RICHARD E ROTHMAN
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Bench-to-Bedside: Identification of Predictive Biomarkers of Asthma Exacerbation
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项目类别:
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资助金额:$5.0万
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项目类别:
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资助金额:$33.8万
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财政年份:--
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负责人:RICHARD E ROTHMAN
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依托单位:
海外基金