Developmental Research Program

发展研究计划

• 批准号: 7507398
• 负责人: Jack Roth
• 金额: $ 5.86万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2013-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7507398
• 关键词: American Cancer Society; Award; Basic Science; Bioinformatics; Biostatistics Core; Budgets; Cancer Center; Cessation of life; Clinical; Clinical Research; Collaborations; Collection; Data; Development; Direct Costs; Educational process of instructing; Environment; Faculty; Foundations; Funding; Funding Agency; Goals; Grant; Guidelines; Human; Incidence; Institution; Joints; Laboratories; Letters; Malignant neoplasm of lung; Mentors; Mentorship; Monitor; Morbidity - disease rate; Nature; Pathology; Peer Review; Pilot Projects; Play; Preparation; Process; Progress Reports; Purpose; Quality Control; RNA; Records; Reporting; Reproduction spores; Research; Research Personnel; Research Project Grants; Resources; Role; Scientist; Selection Criteria; Staging; Stress; Structure; Texas; Tobacco; Translating; Translational Research; Universities; University of Texas M D Anderson Cancer Center; Videoconferences; Videoconferencing; Work; Writing; anticancer research; aptamer; austin; base; cancer therapy; career; design; innovation; programs; tissue resource

PROGRAM SUMMARY SPORE guidelines mandate diligent efforts to identify and fund pilot projects to explore innovative ideas that may eventually reduce the incidence and morbidity or increase the survival of lung cancer. Both UTSW and UTMDACC have significant records in obtaining and administering development funds via the SPORE and outside funds and have found the SPORE Developmental Research Program to be one of the most valuable and productive of the SPORE components. UTSW has a -25-year track record of administering developmental funds for cancer research. These funds are available through the American Cancer Society (ACS) Institutional Grant IN-142. The ACS funds must be distributed to new investigators in cancer research whose proposed pilot projects are especially worthy and likely to gain national grant support through the peer-review mechanism. At UTMDACC, more than $1,000,000 in development funds is made available yearly from clinical revenues to both clinical and basic science faculty for development projects. In addition, the UTMDACC Co-Pi (Jack Roth) has administered a developmental research program in innovative cancer therapies funded by the W. M. Keck Foundation using an external peer-review mechanism. This additional funding underscores UTMDACC's commitment to translational research and provides additional support for development projects. As part of the UTSW and UTMDACC renewed commitment to the SPORE, an additional $150,000 from Texas Tobacco Settlement Funds and other institutional funds will be made available from UTSW ($50,000) and UTMDACC ($100,000) for Lung Cancer SPORE Developmental Research Projects. The development of innovative research ideas in lung cancer is critically dependent on the availability of flexible funding for pilot projects. The purpose of the SPORE Developmental Research Program is to encourage and develop laboratory research projects that will result in clinically testable hypotheses with potential for reducing lung cancer incidence or morbidity or for increasing survival. Both laboratory and clinical research projects are eligible for funding, provided they are translational in nature. A proportion of the SPORE NCI budget ($100,000 in direct costs, $50,000 to Developmental Projects and $50,000 to Career Development Projects - see Career Development Section) will be allocated yearly to support pilot projects at both UTSW and UTMDACC. These allocations fulfill the SPORE Guideline requirements for budgeting. However, we stress, this will be combined with a yearly UTSW and MDACC institutional commitment of $150,000 (UTSW $50,000 and MD Anderson Cancer Center $100,000) which represent $150,000 for Developmental Projects plues $50,000 from the SPORE.. Thus, the combined UTSW + MDACC total from NCI and Institutional funds for Lung Cancer SPORE Developmental Projects is $200,000. Such funding will be limited to a maximum of $50,000 per year per project, however, most of the awards are for ~$25,000 per project for a total of ~8 Developmental Projects awarded per year. Funding will be for one year and will be renewable for one additional year. While the budget divides the $100,000 in direct costs equally between the two institutions, the SPORE Developmental Program will allocate funding based on merit using the review process described in a later section. These projects may, and often involve collaborations between UTSW and UTMDACC investigators particularly given the use of SPORE resources such as the SPORE Pathology Core B, Biostatistics Core C, and Bioinformatics Core D, which greatly augment the translational capability of the Developmental Awards. These projects may also be awarded to investigators at other institutions. For example Dr. Andrew Ellington on the faculty of UT Austin received a Development award for deriving RNA aptamers specific for lung cancer.

节目概要 SPORE指导方针要求勤奋努力，以确定和资助试点项目，以探索创新的想法， 可能最终降低肺癌的发病率和发病率或增加肺癌的存活率。UTSW和 UTMDACC在通过SPORE获得和管理发展资金方面有着重要的记录， 外部资金，并发现SPORE发展研究计划是最有价值的项目之一 和生产孢子成分。UTSW拥有25年的发展管理记录， 癌症研究的资金。这些资金可通过美国癌症协会（ACS）机构 第142章. ACS的资金必须分配给癌症研究的新研究者， 试点项目尤其值得通过同行评审获得国家赠款支持 机制在UTMDACC，每年有超过1，000，000美元的开发资金可用于临床 临床和基础科学学院的发展项目的收入。此外，UTMDACC Co-Pi (Jack Roth）管理了一项由美国癌症研究所资助的创新癌症疗法的发展研究计划。 W. M.凯克基金会使用外部同行评审机制。这笔额外的资金强调了 UTMDACC致力于转化研究，并为开发项目提供额外的支持。 作为UTSW和UTMDACC对SPORE重新承诺的一部分， 德克萨斯州烟草结算基金和其他机构基金将从UTSW获得 （50，000美元）和UTMDACC（100，000美元）用于肺癌孢子发展研究项目。 肺癌创新研究思路的发展关键取决于 为试点项目提供灵活的资金。SPORE发展研究计划的目的是 鼓励和发展实验室研究项目，这将导致临床可检验的假设， 降低肺癌发病率或发病率或增加存活率的潜力。实验室和临床 研究项目如属翻译性质，便可获得资助。孢子的一部分 NCI预算（直接成本100，000美元，发展项目50，000美元，职业发展50，000美元 项目-见职业发展部分）将每年分配，以支持两个UTSW的试点项目 和UTMDACC。这些分配符合SPORE指导方针的预算要求。但我们 强调，这将与每年15万美元UTSW和MDACC机构承诺相结合（UTSW 50，000美元和MD安德森癌症中心100，000美元），其中150，000美元用于发展项目 5万元从SPORE..因此，来自NCI和机构的UTSW + MDACC合计 肺癌孢子发展项目的资金是20万美元。这些资金将仅限于 每个项目每年最多50，000美元，然而，大多数奖项的总金额为每个项目约25，000美元 每年约有8个开发项目。资助期限为一年，可续延一年 额外的一年。虽然预算将10万美元的直接费用平均分配给两个机构， SPORE发展计划将使用 后段。这些项目可能，并且经常涉及UTSW和UTMDACC之间的合作 研究人员特别考虑到使用孢子资源，如孢子病理学核心B， 生物统计学核心C和生物信息学核心D，这大大增强了翻译能力。 发展奖。这些项目也可授予其他机构的调查人员。例如 博士UT奥斯汀学院的Andrew Ellington因衍生RNA适体而获得发展奖 对肺癌有特效