Pilot Projects and Trans-Network Activities

试点项目和跨网络活动

• 批准号: 10681977
• 负责人: Jack Roth
• 金额: $ 8.25万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-30 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10681977
• 关键词: Clinic; Clinical; Communication; Data; Data Commons; Development; Discipline; Environment; Funding; Generations; Mentorship; Methods; Molecular; Peer Review; Pharmaceutical Preparations; Pilot Projects; Research; Research Personnel; Scientist; Seeds; Texas; Training; Translating; Universities; University of Texas M D Anderson Cancer Center; data sharing; drug development; flexibility; novel; programs; research and development; response

Abstract This Pilot Projects Program (PPP) provides, after selection by external review and applicant discussion with senior UTPDTC investigators, a flexible and nimble platform for seed funding of novel research that has potential to significantly impact PDX and drug development research.We have the following Specific Aims: 1. Provide PPP funding to projects focused on PDX and drug development research. 2. Use the expertise of MDACC and UTSW scientific and clinical leaders and PDXNet investigators and Core leaders to identify high impact PDX and drug pilot projects in the UTMDACC, UTSW, PDXNet, and related environments. 3. Build on well- established mechanisms at UTMDACC and UTSW for mentorship of and integration with PDXNet investigators, Projects, and Cores. 4. Build on the existing PDXNet framework to promote communication between basic and clinical scientists, within and outside UTMDACC and UTSW, across disciplines, and guide the training of a new generation of PDX and drug development researchers. 5. Facilitate development and transition of these successful projects into competitive applications for peer-reviewed funding. 6. Build on existing PDXNet mechanisms to translate the findings into the clinic. Pilot Projects and Trans-Network Activities Core will interact with other Network units in the development of trans-Network collaborative projects, and will also assist non- Network investigators chosen to participate in PDXNet by NCI. Close interaction will be maintained with the PDCCC PDX Data Commons and Coordinating Center in terms of sharing data regarding PDX demographic information, molecular characterization and response to agents, and jointly developing methods to analyze data.

摘要 该试点项目计划（PPP）在经过外部审查和申请人讨论后， 高级UTPDTC调查员，一个灵活敏捷的平台，为具有潜力的新研究提供种子资金 显著影响PDX和药物开发研究。我们有以下具体目标：1.提供 PPP为专注于PDX和药物开发研究的项目提供资金。2.利用MDACC的专业知识， UTSW的科学和临床领导者以及PDXNet研究人员和核心领导者，以确定高影响力的PDX UTMDACC、UTSW、PDXNet和相关环境中的药物试点项目。3.好好建设- 在UTMDACC和UTSW建立机制，以指导和整合PDXNet调查人员， 项目和核心。4.在现有PDXNet框架的基础上，促进基础和 临床科学家，内部和外部UTMDACC和UTSW，跨学科，并指导培训新的 PDX和药物开发研究人员的一代。5.促进发展和过渡这些 成功的项目转化为竞争性申请，以获得同行评审的资金。6.基于现有PDXNet构建 将研究结果转化为临床的机制。试点项目和跨网络活动核心将相互作用 与其他网络单位合作开发跨网络合作项目，还将协助非网络单位， NCI选择参与PDXNet的网络调查人员。将与联合国维持密切互动， PDCCC PDX数据共享和协调中心，共享有关PDX人口统计的数据 信息、分子表征和对病原体的反应，并联合开发分析数据的方法。