Microenvironmental Impact in the Treatment of Acute Lymphoblastic Leukemia

急性淋巴细胞白血病治疗中的微环境影响

• 批准号: nhmrc : 1042305
• 负责人: A/Pr Linda Bendall
• 金额: $ 41.44万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/microenvironmental-impact-treatment-lymphoblastic-leukemia/111453
• 关键词: Microenvironmental; Impact; Treatment; Acute; Lymphoblastic

Acute lymphoblastic leukemia remains one of the leading causes of death in children and outcomes for adults with this disease remain poor. This project examines how manipulation of the environment where leukemia arises can be used to therpaeutic advancage. Acute lymphoblastic leukemia cells are highly dependent on the support provided by bone marrow cells but the mechanisms are not well understood. Disrupting signals from the bone marrow cells has potential as a therapeutic strategy.

急性淋巴细胞白血病仍然是儿童死亡的主要原因之一，患有这种疾病的成年人的结果仍然很差。该项目研究了如何操纵白血病发生的环境可以用于治疗进展。急性淋巴细胞白血病细胞高度依赖于骨髓细胞提供的支持，但其机制尚不清楚。破坏来自骨髓细胞的信号有可能成为一种治疗策略。