Adiponectin and cholesterol: A driving force in NASH immunopathogenesis

脂联素和胆固醇：NASH 免疫发病机制的驱动力

• 批准号: nhmrc : 1049857
• 负责人: A/Pr Linda Bendall
• 金额: $ 29.07万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/adiponectin-cholesterol-driving-nash-immunopathogenesis/112116
• 关键词: Adiponectin; cholesterol; driving; force; NASH

This project examined the role of dietary cholesterol in the pathogenesis of fatty liver disease in a rodent model. We have been able to demonstrate that diets high in cholesterol lead to the development of inflammatory foci in the liver, elevations in the amount of hepatic ceramides (a lipid byproduct) and then leads to the activation of inflammatory molecular pathwways that lead to liver fibrosis. The latter results in end stage liver disease, and in some to the development of liver cancer.

该项目在啮齿动物模型中研究了膳食胆固醇在脂肪肝疾病发病机制中的作用。我们已经证明，高胆固醇饮食会导致肝脏炎症灶的形成、肝神经酰胺（一种脂质副产品）含量升高，然后导致炎症分子途径激活，从而导致肝纤维化。后者会导致终末期肝病，并且在某些情况下会发展为肝癌。