Microenvironmentally Induced Acute Lymphoblastic Leukemia Cell Quiescence and Chemotherapy Evasion

微环境诱导的急性淋巴细胞白血病细胞静止和化疗逃避

• 批准号: nhmrc : 1041614
• 负责人: A/Pr Linda Bendall
• 金额: $ 44.87万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/microenvironmentally-induced-acute-chemotherapy-evasion/111381
• 关键词: Microenvironmentally; Induced; Acute; Lymphoblastic; Leukemia

Although almost all patients with ALL achieve a remission, a proportion of children and the majority of adults relapse following treatment. Relapse occurs as a result of a small number of malignant cells that survive chemotherapy. We have identified a population of quiescent cells that could represent this population. We believe this population is defined by its location in the bone marrow. This project will characterize this population and determine whether it is protected from chemotherapy.

尽管几乎所有的all患者都获得了缓解，但仍有一部分儿童和大多数成人在治疗后复发。复发是由于少数恶性细胞在化疗中存活下来。我们已经确定了一个可以代表这个群体的静止细胞群。我们认为这个群体是由它在骨髓中的位置决定的。该项目将对这一人群进行特征描述，并确定他们是否可以免受化疗的影响。