Acute Lymphoblastic Leukemia and the Bone Marrow Microenvironment

急性淋巴细胞白血病和骨髓微环境

• 批准号: nhmrc : 511965
• 负责人: A/Pr Linda Bendall
• 金额: $ 28.06万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/acute-lymphoblastic-leukemia-marrow-microenvironment/115612
• 关键词: Acute; Lymphoblastic; Leukemia; Bone; Marrow

This research aims to identify new drugs for the treatment of childhood and adult acute lymphoblastic leukemia (ALL). We have identified drugs that interfere with interactions between the bone marrow and leukemic cells and hypothesise that these will increase the potency of currently used chemotherapy. We will test these agents in animal models of human leukemia. By analysing the effects of these new drugs we will also understand how we can further improve treatments.

这项研究旨在寻找治疗儿童和成人急性淋巴细胞白血病（ALL）的新药。我们已经确定了干扰骨髓和白血病细胞之间相互作用的药物，并假设这些药物将增加目前使用的化疗的效力。我们将在人类白血病动物模型中测试这些药物。通过分析这些新药的效果，我们还将了解如何进一步改进治疗。