Psychosocial Influences on Nociception

社会心理对伤害感受的影响

• 批准号: 7584612
• 负责人: Anne Courtney DeVries
• 金额: $ 33.75万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-29 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7584612
• 关键词: Acute; Adrenal Cortex Hormones; Affect; Animals; Anxiety; Awareness; Behavior; Behavioral; Buffers; Chronic stress; Cognitive deficits; Corticosterone; Cytokine Activation; Data; Development; Exhibits; Exposure to; Foundations; Glucocorticoid Receptor; Goals; Hormonal; Hormones; House mice; Housing; Human; Individual; Individual Differences; Inflammation; Inflammatory; Inflammatory Response; Knockout Mice; Lead; Manuscripts; Measures; Mechanics; Mediating; Mental Depression; Modeling; Mus; Nociception; Operative Surgical Procedures; Outcome; Oxytocin; Oxytocin Receptor; Pain; Pain Threshold; Pathogenesis; Patients; Pattern; Peer Review; Peripheral nerve injury; Persistent pain; Pharmaceutical Preparations; Pharmacotherapy; Physiological; Prevention approach; Public Health; Quality of life; Rate; Relative (related person); Sleep disturbances; Social Aspects of Cancer; Social Environment; Social Interaction; Social support; Spinal cord posterior horn; Stimulus; Stress; Symptoms; Syndrome; Testing; Therapeutic; Time; Tissues; Wild Type Mouse; acute stress; allodynia; chronic pain; improved; insight; mouse model; nerve injury; neuroinflammation; painful neuropathy; prevent; psychologic; response; social

DESCRIPTION (provided by applicant): Both psychological and physiological factors contribute to individual differences in nociception. The current proposal examines the effects of stress and social support on nociception and the physiological mechanisms through which these psychological constructs influence nociceptive behavior. We will use a spared nerve injury model in mice to 1) define the parameters under which stress affects nociception, 2) to evaluate the importance of hormonal and inflammatory responses in mediating stress-induced increases in allodynia, 3) to determine the physiological mechanisms through which social interaction decreases allodynia, and 4) determine whether social interaction can mitigate the effects of stress on nociception. The overall hypothesis is that stress will decrease, and social interaction will increase, nociceptive thresholds through a mechanism that involves altered corticosteroid exposure. The data collected as part of this proposal will increase our understanding of the how psychological variables, such as stress and social support, affect nociceptive thresholds. Ultimately, a better understanding of the pathogenesis of neuropathic pain could facilitate the development of therapeutic approaches for the prevention and treatment of pain-related syndromes in humans and other animals. PUBLIC HEALTH RELEVANCE Pain serves a very important, adaptive, function of increasing awareness of noxious stimuli as a means of preventing or limiting tissue damage, however, when pain becomes intractable or is elicited by typically innocuous stimuli, then it becomes debilitating to the individual and negatively impacts quality of life. The overarching goal of this proposal is to provide insights into the physiological mechanisms underlying psychosocial influences on pain, in hopes of better understanding the factors that contribute to individual differences in the development and expression pain behaviors. Improved understanding of the physiological mechanisms underlying pain behavior is expected to lead to improved treatment of pain in humans.

描述（由申请人提供）：心理和生理因素都有助于伤害感受的个体差异。目前的建议是研究压力和社会支持对伤害感受的影响，以及这些心理结构影响伤害感受行为的生理机制。我们将在小鼠中使用备用神经损伤模型来1）定义压力影响伤害感受的参数，2）评估激素和炎症反应在介导压力诱导的异常性疼痛增加中的重要性，3）确定社会互动减少异常性疼痛的生理机制，以及4）确定社会互动是否可以减轻压力对伤害感受的影响。总的假设是，压力会降低，社会交往会增加，伤害性阈值通过一种机制，涉及改变皮质类固醇暴露。作为该提案的一部分，收集的数据将增加我们对心理变量（如压力和社会支持）如何影响伤害性阈值的理解。最终，更好地了解神经性疼痛的发病机制可以促进预防和治疗人类和其他动物疼痛相关综合征的治疗方法的发展。公共卫生相关性疼痛作为预防或限制组织损伤的一种手段，具有增加对有害刺激的意识的非常重要的适应性功能，然而，当疼痛变得顽固或由通常无害的刺激引起时，它会使个体衰弱并对生活质量产生负面影响。该建议的总体目标是提供对疼痛的心理社会影响的生理机制的见解，希望更好地理解有助于发展和表达疼痛行为的个体差异的因素。对疼痛行为背后的生理机制的更好理解有望改善人类疼痛的治疗。