Resistance Training as an Aid to Standard Smoking Cessation Treatment

描述(申请人提供)：吸烟仍然是美国成年人死亡的首要、可预防的原因；然而，大约20.9%的美国成年人继续吸烟。戒烟后对体重增加和情绪相关戒断症状的担忧是复发的已知预测因素。之前的大规模干预试验表明，锻炼是戒烟的有益辅助治疗，因为它对体重担忧和负面情绪状态都有积极影响。然而，这些试验中的大多数只关注女性，也只关注有氧运动。阻力训练(即举重)也可能为吸烟者提供一个有益的戒烟辅助策略，因为它也可以改善情绪和控制体重。因此，拟议的试点研究将测试抵抗力训练计划的有效性，以帮助健康的成年男性和女性吸烟者进行标准的戒烟治疗。具体地说，我们计划在60名健康男性和女性中比较标准戒烟治疗加上为期12周的抵抗力训练计划和相同标准戒烟治疗加上同等接触控制的效果。将通过一氧化碳[和自我报告]来验证戒烟结果([长期]戒烟和点流行戒烟)。治疗后12周和[3个月]停药率在不同情况下的差异将为充分有效的临床试验提供功率估计数据。吸烟是美国人的第二大死亡原因，因为在美国，每四个死亡中就有一个是吸烟造成的。因此，这项建议旨在通过进一步阐明戒烟的作用机制来应对这一公共卫生问题。它还有可能发现另一种帮助吸烟者戒烟的方法。

DESCRIPTION (provided by applicant): Cigarette smoking continues to be the leading, preventable cause of death among American adults; however, approximately 20.9% of US adults continue to smoke. Concerns about weight gain and mood-related withdrawal symptoms following smoking cessation are known predictors of relapse. Previous large-scale intervention trials indicate that exercise is a beneficial adjunct treatment for smoking cessation, as it positively impacts both weight concerns and negative mood states. The majority of these trials, however, have focused only on women, and only on aerobic exercise. Resistance training (i.e., weight lifting), may also offer smokers a beneficial adjunctive strategy to quit smoking, as it too can both improve mood and manage body weight. As such, the proposed pilot study will test the efficacy of a resistance training program as an aid to standard smoking cessation treatment on cessation among healthy adult male and female smokers. Specifically, we plan to compare the effects of a standard smoking cessation treatment, plus a 12-week resistance training program to the same standard smoking cessation treatment plus equivalent contact control among 60 healthy men and women. Smoking cessation outcomes ([prolonged] abstinence and point prevalence abstinence) will be verified by carbon monoxide [and self-report.] Differences in post-treatment 12-week and [3-month] cessation rates between conditions will provide data for power estimates for an adequately powered clinical trial. Cigarette smoking is the second leading cause of death among Americans, as it is responsible for one out of every four deaths in the United States. As such, this proposal represents an effort to combat this public health problem by further elucidating the mechanisms of action involved in smoking cessation. It also carries the potential to discover an additional way to assist smokers in quitting smoking.