Resistance Training as an Aid to Standard Smoking Cessation Treatment

描述（由申请人提供）：吸烟仍然是美国成年人死亡的主要可预防原因;然而，大约20.9%的美国成年人继续吸烟。戒烟后对体重增加和情绪相关的戒断症状的担忧是已知的复吸预测因素。以前的大规模干预试验表明，运动是戒烟的有益辅助治疗，因为它对体重问题和消极情绪状态都有积极影响。然而，这些试验中的大多数只关注女性，而且只关注有氧运动。阻力训练（即，举重），也可以为吸烟者提供一个有益的戒烟策略，因为它也可以改善情绪和管理体重。因此，拟议的试点研究将测试阻力训练计划作为标准戒烟治疗的辅助手段对健康成年男性和女性吸烟者戒烟的有效性。具体来说，我们计划在60名健康男性和女性中比较标准戒烟治疗加上12周阻力训练计划与相同标准戒烟治疗加上等效接触控制的效果。将通过一氧化碳[和自我报告]验证戒烟结局（[长期]戒烟和点戒烟率）。不同疾病之间治疗后12周和[3个月]戒烟率的差异将为充分把握度临床试验的把握度估计提供数据。吸烟是美国人死亡的第二大原因，因为在美国，每四个死亡中就有一个是由吸烟造成的。因此，该提案代表了通过进一步阐明戒烟所涉及的作用机制来应对这一公共卫生问题的努力。它还具有发现帮助吸烟者戒烟的额外方法的潜力。

DESCRIPTION (provided by applicant): Cigarette smoking continues to be the leading, preventable cause of death among American adults; however, approximately 20.9% of US adults continue to smoke. Concerns about weight gain and mood-related withdrawal symptoms following smoking cessation are known predictors of relapse. Previous large-scale intervention trials indicate that exercise is a beneficial adjunct treatment for smoking cessation, as it positively impacts both weight concerns and negative mood states. The majority of these trials, however, have focused only on women, and only on aerobic exercise. Resistance training (i.e., weight lifting), may also offer smokers a beneficial adjunctive strategy to quit smoking, as it too can both improve mood and manage body weight. As such, the proposed pilot study will test the efficacy of a resistance training program as an aid to standard smoking cessation treatment on cessation among healthy adult male and female smokers. Specifically, we plan to compare the effects of a standard smoking cessation treatment, plus a 12-week resistance training program to the same standard smoking cessation treatment plus equivalent contact control among 60 healthy men and women. Smoking cessation outcomes ([prolonged] abstinence and point prevalence abstinence) will be verified by carbon monoxide [and self-report.] Differences in post-treatment 12-week and [3-month] cessation rates between conditions will provide data for power estimates for an adequately powered clinical trial. Cigarette smoking is the second leading cause of death among Americans, as it is responsible for one out of every four deaths in the United States. As such, this proposal represents an effort to combat this public health problem by further elucidating the mechanisms of action involved in smoking cessation. It also carries the potential to discover an additional way to assist smokers in quitting smoking.