TYPE II DIABETES IN ADOLESCENTS, COGNITION, AND THE BRAIN

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 关于青少年2型糖尿病患者存在认知功能障碍的信息有限。 有证据支持1型和2型糖尿病成人存在认知功能障碍。 这一群体患病的时间可能比青少年长得多。 有一些证据表明，1型糖尿病儿童存在认知功能障碍，但2型糖尿病儿童则没有。 在本研究中，将评估在儿科内分泌诊所就诊以评估和治疗其肥胖的青少年患者的1）2型糖尿病的存在，2）葡萄糖耐量正常的单独胰岛素抵抗（IR），和3）IR或糖尿病的不存在。 然后，他们将参加一项研究，该研究将使用一系列神经心理学测试来评估糖尿病患者的潜在认知缺陷。最后，他们将接受大脑MRI（DT-MRI），在概述的特定区域中寻找髓鞘形成和大小的差异。 主要的假设是青少年糖尿病患者的神经心理学评分较低。 他们还将探讨IR，神经精神测试结果和MRI变量之间的相关性。 将招募50名患者。 这项试点研究将为随后的更大规模研究提供初步数据。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There is limited information regarding the presence of cognitive dysfunction in adolescents with type 2 diabetes. There is evidence provided to support the presence of cognitive dysfunction in adults with both type 1 and 2 diabetes. This group has probably had disease for considerably longer than the adolescents. There is some evidence of cognitive dysfunction in children with type 1 diabetes but not those with type 2. In this study, adolescent patients seen in the pediatric endocrine clinic for evaluation and treatment of their obesity will be assessed for 1) the presence of type 2 diabetes, 2) insulin resistance (IR) alone with normal glucose tolerance, and 3) the absence of IR or diabetes. They will then be enrolled into a study that will evaluate potential cognitive defects in those with diabetes using a battery of neuropsychological tests. Finally, they will receive a brain MRI (DT-MRI), looking for differences in myelination and size, in specific regions outlined. The main hypothesis is that there will be lower neuropsychologic scores in adolescents with diabetes. They will also explore correlations between IR, neuropsychiatric test results and MRI variables. Fifty patients are to be enrolled. This pilot study would provide initial data for a subsequent larger study.