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Diabetes, Cognition and the Brain

糖尿病、认知和大脑

基本信息

批准号：
8674736
负责人：
ANTONIO CONVIT
金额：
$ 21.77万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-01-01 至 2015-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8674736
关键词：
Affect Age Age-Years Animals Anti-Inflammatory Agents Anti-inflammatory Basic Science Blood Blood Vessels Brain Brain region C-reactive protein Carbon Dioxide Cephalic Cerebrovascular Circulation Cerebrum Code Cognition Cognitive Coupled Data Data Reporting Diabetes Mellitus Discipline of Nursing Disease Disease Progression Education Elderly Emergency Situation Endocrine Environment Equipment Evaluation Fibrinogen Floods Functional disorder Funding Gender Goals Grant Healthcare Heating Hippocampus (Brain)Hospitals Hyperglycemia Hypertension Impairment Individual Inflammation Institutes Insulin Insulin Resistance Interleukin-6 Lateral Lead Link Literature Magnetic Resonance Imaging Measures Mechanics Mediating Medical Medical center Memory Memory impairment Metabolic Methods Modeling Neurons Neuropsychological Tests New York City Non-Insulin-Dependent Diabetes Mellitus Obesity Oxidative Stress Parietal Lobe Patient Care Patients Performance Peripheral Phase Play Plumbing Procedures Process Progress Reports Race Reporting Research Rest Role Safety Sampling Science Side Site Specificity Spin Labels System Techniques Temporal Lobe Testing Time Tissues Tumor Necrosis Factor-alpha Work adiponectin advanced disease base brain volume cerebral atrophy cognitive function design endothelial dysfunction experience falls frontal lobe frontal lobe function glucose tolerance glycemic control human TNF protein improved inflammatory marker insulin sensitivity intravenous glucose tolerance test middle age non-diabetic novel respiratory wasting

项目摘要

NYU Langone Medical Center experienced an unprecedented storm on October 29th, 2012, causing damage that deeply impacted our patient care, research, and educational facilities. NYULMC’s emergency power system was designed and built according to all safety codes to withstand a surge higher than the highest flood level for New York City in the past century. Superstorm Sandy obviously exceeded those levels. Although we safely evacuated over 300 patients from Tisch Hospital and Schwartz Health Care Center (HCC) in the midst of the storm, our main campus incurred extensive damage to its mechanical, electrical, and plumbing systems, requiring the temporary closure of our main campus. There are three basic science buildings, the Skirball Institute, the Smilow Research Center, and the Medical Science Building (MSB). The below-ground levels of two of these buildings, the Smilow Research Center and MSB, which included two vivarium facilities, were significantly damaged. The animal vivarium of Smilow was deemed completely unrecoverable. The MSB vivarium remains closed. While Skirball and Smilow were operational within two months post- Sandy, MSB remains closed and its phased reopening is expected to begin this summer. In addition, Bellevue Hospital, where the CTSI is located and where we conduct the evaluations that require skilled nursing assistance, was closed for over 3 months.

2012年10月29日，纽约大学朗格尼医学中心经历了一场前所未有的风暴，对我们的病人护理、研究和教育设施造成了严重影响。 NYULMC的应急电源系统是根据所有安全规范设计和建造的，经受住了超过纽约市在过去世纪最高洪水水位的冲击。超级风暴桑迪显然超过了这些水平。尽管我们安全疏散了300多名来自Tisch医院和Schwartz医疗保健中心（HCC）的患者在风暴中，我们的主校区在机械、电气和管道方面遭受了大规模的破坏系统，需要暂时关闭我们的主校区。有三个基础科学建筑，Skirball研究所，Smilow研究中心，医学科学大楼（MSB）其中两栋建筑的地下楼层， Smilow研究中心和MSB，包括两个动物园设施，损坏Smilow的动物饲养场被认为完全不可恢复。的MSB 动物园仍然关闭。虽然Skirball和Smilow在两个月后开始运作，桑迪，MSB仍然关闭，其分阶段重新开放预计将于今年夏天开始。在此外，CTSI所在的贝尔维尤医院也是我们进行评估的地方需要熟练护理人员协助的诊所关闭了3个多月。

项目成果

期刊论文数量（12）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Neural substrates of verbal memory impairments in adults with type 2 diabetes mellitus.

DOI：
10.1080/13803395.2013.869310
发表时间：
2014
期刊：
Journal of clinical and experimental neuropsychology
影响因子：
2.2
作者：
Yau PL;Kluger A;Borod JC;Convit A
通讯作者：
Convit A

BMI modulates calorie-dependent dopamine changes in accumbens from glucose intake.

BMI 通过葡萄糖摄入调节伏隔核中热量依赖性多巴胺的变化。

DOI：
10.1371/journal.pone.0101585
发表时间：
2014
期刊：
PloS one
影响因子：
3.7
作者：
Wang,Gene-Jack;Tomasi,Dardo;Convit,Antonio;Logan,Jean;Wong,ChristopherT;Shumay,Elena;Fowler,JoannaS;Volkow,NoraD
通讯作者：
Volkow,NoraD

Obesity-mediated inflammation may damage the brain circuit that regulates food intake.