Obesity, Insulin Resistance and Brain in Adolescence

青春期肥胖、胰岛素抵抗和大脑

• 批准号: 8675057
• 负责人: ANTONIO CONVIT
• 金额: $ 19.96万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-01-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8675057
• 关键词: 21 year old; Address; Adolescence; Adolescent; Adult; Affect; Age; Appearance; Area; Attention; Base of the Brain; Biological Assay; Brain; Cerebrum; Cognition; Cognitive; Complex; Data; Data Set; Education; Endocrine; Ensure; Ethnic Origin; Evaluation; Female; Functional disorder; Funding; Gender; Heterogeneity; Hippocampus (Brain); Hispanics; Human Resources; Hurricane; Impaired cognition; Individual; Inflammation; Insulin; Insulin Resistance; Laboratories; Link; Literature; Magnetic Resonance Imaging; Measurable; Measures; Mediating; Memory; Metabolic; Nature; Neuropsychological Tests; Non obese; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Performance; Procedures; Publications; Race; Relative (related person); Resistance; Running; Sampling; Socioeconomic Status; Study Subject; Testing; Time; Tissues; Wages; base; case control; cost; design; diabetic; ethnic minority population; executive function; experience; fasting glucose; frontal lobe; gray matter; inflammatory marker; middle age; neuropsychological; neurotrophic factor; response; white matter

Type 2 diabetes mellitus (T2DM) in middle-aged individuals has been consistently associated with deficits in recent memory, attention, executive function, and cognitive efficiency. Insulin resistance (IR) is a progressive pre-diabetic condition. We have strong preliminary evidence that similar cognitive problems are also present among obese adolescents with IR relative to matched non-insulin resistant groups. The purpose of the proposed study is to rigorously establish the nature of the cognitive impairments present among obese adolescents with IR and by means of a systematic and standardized neuropsychological and MRI-approach to further characterize the brain substrates for those abnormalities. In addition, we propose to ascertain whether, relative to matched lean adolescents, obese adolescents without insulin resistance have detectable cognitive impairments. Obesity and IR are associated with inflammation. Thus, we will also assess whether inflammation mediates some of the associations between IR (and/or obesity) and brain dysfunction in adolescence. We seek funds to mitigate the effects of Hurricane Sandy and facilitate the successful completion of the Specific Aims of our proposal, which are: Specific Aim I: To determine whether obese adolescents with insulin resistance have lower performance on memory and other cognitive domains relative to matched obese non-insulin resistant and lean adolescents. Specific Aim II: To determine whether obese adolescents with insulin resistance have MRI-based hippocampal volume reductions, gray matter reductions, and white matter abnormalities. Specific Aim III: To determine whether among obese adolescents markers of inflammation mediate the hypothesized links between insulin resistance and reductions in cognitive performance, hippocampal volume reductions, reductions in gray matter, and reductions in white matter integrity. Funds will be used for: - Salary of personnel for time spent either in lockout, damage assessment, re-establishing the laboratory, running additional subjects to complete the aims - Supplies costs that are needed to complete the aims; - Extra assays on stored samples needed to complete the aims We estimate that we will need 6 months to make up for the time lost due to Sandy.

中年人的2型糖尿病（T2 DM）一直与以下缺陷相关： 近期记忆、注意力、执行功能和认知效率。胰岛素抵抗（IR）是一种渐进的 糖尿病前期我们有强有力的初步证据表明，类似的认知问题也存在 肥胖青少年胰岛素抵抗组与非胰岛素抵抗组相比。的目的 一项拟议的研究是严格确定肥胖人群中存在的认知障碍的性质， 青少年IR和通过系统和标准化的神经心理学和MRI方法， 进一步描述这些异常的大脑基质。此外，我们建议确定， 相对于匹配的瘦青少年，无胰岛素抵抗的肥胖青少年具有可检测的认知能力， 损伤肥胖和IR与炎症相关。因此，我们还将评估炎症是否 介导IR（和/或肥胖）与青春期脑功能障碍之间的一些关联。 我们寻求资金，以减轻飓风桑迪的影响，并促进成功完成 我们建议的具体目标是： 具体目标I：确定患有胰岛素抵抗的肥胖青少年是否表现较低 记忆和其他认知领域相对于匹配的肥胖非胰岛素抵抗和瘦青少年。 具体目标II：确定肥胖青少年胰岛素抵抗是否有基于MRI的海马 体积减少、灰质减少和白色物质异常。 具体目标III：确定肥胖青少年中炎症标志物是否介导肥胖的发生。 胰岛素抵抗与认知能力、海马体积、 减少、灰质减少和白色物质完整性减少。 资金将用于： - 人员在停工、损害评估、重建实验室、 运行额外的科目，以完成目标 - 完成目标所需的用品费用; - 完成目标所需的储存样本的额外分析 我们估计需要6个月的时间来弥补因桑迪而损失的时间。