CHRONIC KIDNEY DISEASE IN CHILDREN STUDY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 国家糖尿病、消化和肾脏疾病研究所（NIDDK）的肾脏、泌尿和血液疾病部门（DKUHD）与国家神经疾病和中风研究所（NINDS）、国家儿童健康和人类发育研究所（NICHD）和国家心脏病研究所合作，肺和血液研究所（NHLBI）资助了一项合作协议，包括两个临床协调中心和一个数据协调中心，对患有慢性肾脏疾病的儿童进行前瞻性流行病学研究（CKD）。本研究的主要目的是确定肾功能下降的风险因素，并确定肾功能进行性下降如何影响a）神经认知功能和行为; B）心血管疾病的风险因素;和c）生长衰竭及其相关发病率。本前瞻性观察性研究将在4年内招募总计540例慢性肾脏疾病儿童（估计GFR 30-75 ml/min/1.73 m2），并进行一系列检验以研究以下假设。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Division of Kidney, Urologic, and Hematologic Diseases (DKUHD) of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), in collaboration with the National Institute of Neurological Disorders and Stroke (NINDS), the National Institute of Child Health and Human Development (NICHD) and the National Heart, Lung and Blood Institute (NHLBI) funded a cooperative agreement including two Clinical Coordinating Centers and a Data Coordinating Center to conduct a prospective epidemiological study of children with chronic kidney disease (CKD). The primary goals of this study are to determine the risk factors for decline in kidney function and to define how a progressive decline in kidney function impacts a) neurocognitive function and behavior; b) the risk factors for cardiovascular disease; and c) growth failure and its associated morbidity. A total of 540 children with chronic kidney disease (estimated GFR 30-75 ml/min/1.73 m2) will be enrolled in this prospective observational study over 4 years and undergo a series of tests to study the hypotheses given below.