CHRONIC KIDNEY DISEASE IN CHILDREN STUDY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 国家糖尿病、消化和肾脏疾病研究所肾脏、泌尿和血液疾病部DKUHD与国家神经疾病和中风研究所NINDS、国家儿童健康和人类发育研究所NICHD和国家心脏研究所合作，肺和血液研究所NHLBI资助了一项合作协议，包括两个临床协调中心和一个数据协调中心，慢性肾病儿童慢性肾病的流行病学研究。本研究的主要目标是确定肾功能下降的危险因素，并定义肾功能进行性下降如何影响神经认知功能和行为，以及心血管疾病和生长障碍的危险因素及其相关发病率。本前瞻性观察性研究将招募总计540例估计GFR为30-75 ml/min/1.73 m2的慢性肾脏疾病儿童，为期4年，并进行一系列检验以研究以下假设。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Division of Kidney, Urologic, and Hematologic Diseases DKUHD of the National Institute of Diabetes and Digestive and Kidney Diseases NIDDK, in collaboration with the National Institute of Neurological Disorders and Stroke NINDS, the National Institute of Child Health and Human Development NICHD and the National Heart, Lung and Blood Institute NHLBI funded a cooperative agreement including two Clinical Coordinating Centers and a Data Coordinating Center to conduct a prospective epidemiological study of children with chronic kidney disease CKD.The primary goals of this study are to determine the risk factors for decline in kidney function and to define how a progressive decline in kidney function impacts a neurocognitive function and behavior the risk factors for cardiovascular disease and growth failure and its associated morbidity. A total of 540 children with chronic kidney disease estimated GFR 30-75 ml/min/1.73 m2 will be enrolled in this prospective observational study over 4 years and undergo a series of tests to study the hypotheses given below.