OXIDATIVE STRESS CKD

氧化应激性慢性肾病

• 批准号: 7605576
• 负责人: T A IKIZLER
• 金额: $ 2.04万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7605576
• 关键词: Cardiovascular system; Chronic Kidney Failure; Computer Retrieval of Information on Scientific Projects Database; Event; Functional disorder; Funding; Grant; Inflammation; Institution; Link; Oxidative Stress; Patients; Renal function; Research; Research Personnel; Resources; Source; Time; United States National Institutes of Health

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. HYPOTHESES: 1. Increased oxidative stress, inflammation and endothelial dysfunction are biologically linked in patients with chronic kidney disease. 2. Increased oxidative stress, inflammation, and endothelial dysfunction contribute to cardiovascular events in patients with chronic kidney disease. 3. Progressive loss of kidney function over time increases oxidative stress, inflammation, and endothelial dysfunction in patients with chronic kidney disease.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构为 研究中心，而研究中心不一定是研究者所在的机构。 假设： 1. 慢性肾病患者的氧化应激增加、炎症和内皮功能障碍在生物学上存在联系。 2. 氧化应激、炎症和内皮功能障碍的增加可导致慢性肾病患者发生心血管事件。 3. 慢性肾脏疾病患者肾功能随时间进行性丧失会增加氧化应激、炎症和内皮功能障碍。