OXIDATIVE STRESS CKD

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 假设： 1. 慢性肾病患者中氧化应激、炎症和内皮功能障碍的增加与生物学相关。 2. 氧化应激、炎症和内皮功能障碍的增加可导致慢性肾病患者发生心血管事件。 3. 慢性肾脏疾病患者肾功能随时间进行性丧失会增加氧化应激、炎症和内皮功能障碍。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. HYPOTHESES: 1. Increased oxidative stress, inflammation and endothelial dysfunction are biologically linked in patients with chronic kidney disease. 2. Increased oxidative stress, inflammation, and endothelial dysfunction contribute to cardiovascular events in patients with chronic kidney disease. 3. Progressive loss of kidney function over time increases oxidative stress, inflammation, and endothelial dysfunction in patients with chronic kidney disease.