NONINVASIVE ASSESSMENT OF INSULIN RESISTANCE: PHASE I

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 背景：胰岛素抵抗是许多慢性疾病发病机制的标志，并已成为一个主要的健康问题。寻找一种既易于管理又准确的替代非侵入性测试可能会导致更早地检测到胰岛素抵抗，从而使个人能够寻求更早的成本预防治疗方案。 具体目标和程序：长期目标是开发一种非侵入性的胰岛素抵抗测试。 实验设计：每个受试者都有一个筛查期，根据这些结果将被要求返回医院，届时将完成OGTT和呼气测试。所有入院的受试者都将接受外周静脉采血。口服葡萄糖耐量试验是在两个基线血样后给予受试者75克葡萄糖。然后，测试持续10个小时，在选定的时间点进行血液采样。呼气样本将在OGTT的同一时间点采集。受试者将被要求深呼吸，然后整个呼吸通过吸管呼气进入管子。在完全呼气之前，收回吸管，并将螺丝帽放回管子上。 意义：这项研究的成功结果将为制造一种有助于使用非侵入性技术准确检测胰岛素抵抗的产品奠定科学基础。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background: Insulin resistance is the hallmark of pathogenesis of a number of chronic disorders and have become a major health concern. Finding an alternative non-invasive test that is both easy to administer and accurate may lead to earlier detection of insulin resistance, thus enabling individuals to seek earlier cost preventative treatment options. Specific Aims and Procedures: The long term objective to develop a non-invasive test of insulin resistance. Experimental Design: Each subject will have a screening period and based on those results will be asked to return for a hospital admission at which time the OGTT and the breath test will be completed. All admitted subjects will receive a peripherial IV for blood sampling. The OGTT is administered by giving the subject 75 grams of Glucola following 2 baseline blood samples. The test then continues for 10 hours with blood sampling at selected time points. The breath samples will be collected at the same time points as the OGTT. The subject will be asked to take a full breath and then the entire breath is exhaled through a straw into a tube. Before exhaling completely, the straw is withdrawn and the screw cap is replaced on the tube. Significance: A successful outcome of this research will lead to the scientific basis for manufacturing a product that will help to accurately detect insulin resistance by using a noninvasive technique.