PACTG P1061S: EVALUATION OF IMMUNOLOGIC MEMORY FOLLOWING PNEUMOCOCCAL, HEP B

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. P1061S is a follow-up substudy of P1024 "Evaluation of the Immunogenicity of Pneumococcal Conjugate Vaccine and Routine Pediatric Immunizations in HIV-Infected Children Treated with Highly Active Antiretroviral Therapy" to evaluate the persistence of immunologic memory to pneumococcal conjugate vaccine (PCV) and pneumococcal polysaccharide vaccine (PPV), measles vaccine (MMR), and hepatitis B virus (HBV) vaccine in HIV-infected subjects on HAART who participated in, and completed, P1024. The study population is HIV-infected subjects who enrolled into P1024 between June 1, 2001 and March 31, 2002 and completed the initial two-year study period. This includes approximately 224 subjects, out of the original 263 subjects who participated in P1024. Approximately 149 subjects, out of the 224 subjects, are expected to enroll. Enrollment will be completed by January 18, 2006 to allow for the completion of study visits prior to the discontinuation of the PACTG.