DESCRIP OF GASTROINTESTINAL SYMPTOMS IN CHILDREN W/AUTISM COMPARED TO CONTROLS

与对照组相比，自闭症儿童胃肠道症状的描述

• 批准号: 7605071
• 负责人: ANN E REYNOLDS
• 金额: $ 0.15万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7605071
• 关键词: Abdominal Pain; Age; Autistic Disorder; Belief; Brain; Caseins; Centers for Disease Control and Prevention (U.S.); Child; Chronic; Clinical; Cohort Studies; Computer Retrieval of Information on Scientific Projects Database; Constipation; Counseling; Data; Development; Developmental Delay Disorders; Diarrhea; Diet; Disease regression; Etiology; Family; Feces; Fragile X Syndrome; Funding; Future; Genetic; Gluten; Grant; Institution; Neurobehavioral Manifestations; Phenotype; Population; Prevalence; Protocols documentation; Recording of previous events; Research; Research Ethics Committees; Research Personnel; Resources; Source; Specificity; Symptoms; United States National Institutes of Health; autism spectrum disorder; base; day; design; diaries; endophenotype; gastrointestinal; gastrointestinal symptom

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Gastrointestinal symptoms such as diarrhea, constipation and abdominal pain are believed to be common in children with autism spectrum disorders. Many families consider nonstandard therapies due to these beliefs. There is very little data to describe the GI symptoms or to determine whether these symptoms are specific to autism. A better understanding of GI symptoms in autism is critical to appropriately treat children with autism and to move forward with research. This study was designed to examine the prevalence and specificity of GI symptoms in autism using four groups of children. Children with rigorously defined autism are being compared to groups with fragile X syndrome, developmental delay of mixed etiology and to children with typical development. A seven-day stool diary using the Bristol Stool Form Scale to evaluate consistency and a three-day diet diary are being collected in children who are between the ages of 30 and 60 months. Since there is some evidence that an abnormal diet can cause chronic non-specific diarrhea and children with autism frequently have highly restrictive diets, it is important to determine whether diet impacts their GI symptoms. In order to better understand the gastrointestinal phenotype, the relationship between GI symptoms and cognitive level or history of regression will be evaluated. This project is very important in the field of autism from both a research and a clinical standpoint. Phenotypic subtypes and endophenotypes are needed for linkage studies to look for genetic causes of autism. A better understanding of the brain/gut interaction has implications for a better understanding of the etiology of autism and may help with treatment as well. Also many families chose to try the gluten and casein free diet. This project will help design future projects so that information is available to counsel families about the diet. This data will serve as pilot data for a multi-center case-cohort study being conducted by the CDC. This protocol has been included in the larger population based CADDRE/CDC project which has been approved by an external review board and the CDC IRB. The study should begin October 2006.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 据信，腹泻、便秘和腹痛等胃肠道症状在自闭症谱系障碍儿童中很常见。 由于这些信念，许多家庭考虑采用非标准疗法。描述胃肠道症状或确定这些症状是否是自闭症特有的数据非常少。 更好地了解自闭症的胃肠道症状对于适当治疗自闭症儿童和推进研究至关重要。 本研究旨在通过四组儿童检查自闭症胃肠道症状的患病率和特异性。 患有严格定义的自闭症的儿童与患有脆性 X 综合征、混合病因发育迟缓的儿童以及具有典型发育的儿童进行比较。使用布里斯托大便量表评估一致性的 7 天大便日记和 30 至 60 个月大儿童的 3 天饮食日记。 由于有一些证据表明，不正常的饮食会导致慢性非特异性腹泻，并且自闭症儿童经常饮食受到高度限制，因此确定饮食是否会影响他们的胃肠道症状非常重要。 为了更好地了解胃肠道表型，将评估胃肠道症状与认知水平或退化历史之间的关系。从研究和临床角度来看，该项目在自闭症领域都非常重要。 连锁研究需要表型亚型和内表型来寻找自闭症的遗传原因。 更好地了解大脑/肠道相互作用有助于更好地了解自闭症的病因，也可能有助于治疗。 许多家庭也选择尝试无麸质和酪蛋白饮食。 该项目将帮助设计未来的项目，以便为家庭提供有关饮食的信息。该数据将作为疾病预防控制中心正在进行的多中心病例队列研究的试点数据。该协议已包含在基于较大人群的 CADDRE/CDC 项目中，该项目已得到外部审查委员会和 CDC IRB 的批准。 该研究应于 2006 年 10 月开始。