FMRI AND EMOTION IN PERSONALITY DISORDER PATIENTS

FMRI 与人格障碍患者的情绪

• 批准号: 7605289
• 负责人: ANTONIA S NEW
• 金额: $ 0.06万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7605289
• 关键词: Affective; Amygdaloid structure; Anterior; Area; Borderline Personality Disorder; Brain; Brain region; Categories; Clinical; Computer Retrieval of Information on Scientific Projects Database; Development; Diagnosis; Diagnostic; Disease; Emotional; Emotions; Exhibits; Functional Magnetic Resonance Imaging; Functional disorder; Funding; Grant; Institution; Modeling; Mood Disorders; Outcome; Patients; Pattern; Personal Satisfaction; Personality Disorders; Pilot Projects; Prefrontal Cortex; Process; Rate; Research; Research Personnel; Resources; Source; Specificity; Symptoms; United States National Institutes of Health; cingulate cortex; emotion regulation; emotional experience; emotional stimulus; functional disability; neocortical; relating to nervous system; response; service utilization

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Affective instability is a core feature of borderline personality disorder (BPD). It may be associated with significant functional impairment, high rates of service utilization, and negative clinical outcomes. This symptom may be related to an underlying disturbance in the neural processing of emotional stimuli. A recent development in the study of neurobilogical aspects of emotion processing involves exposing a subject to emotional stimuli in functional magnetic resonance imaging. This type of paradigm is consistently associated with activation of subcortical and neocortical brain regions known to be involved in emotional experience and processing of emotional information. Patients with affective disorders exhibit altered responses in several of these brain regions, including amygdala, and anterior cingulate, orbitofrontal and dorsolateral prefrontal cortices. A particularly important functional relationship for emotion regulation may exist between the amygdala and anterior cingulate cortex in these disorders in these disorder. In contrast, the pattern of regional brain activation to emotional stimuli has not been well-investigated in BPD. This application proposes to use fMRI to initiate a pilot study of regional brain response to emotional stimuli, with the prediction that BPD patients will show differences in the activation of areas of the amygdala and cingulate cortex compared to normal controls. Results from this study will be utilized to later examine the clinical specificity of this hypothesized brain brain dysfunction for the symptoms (ie within diagnostic category) and for the diagnosis (ie across diagnostic category) of BPD, and to characterize the temporal and spatial dynamics of emotion processing disturbance in a frontolimbic model of affective instability.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 情感不稳定是边缘型人格障碍的核心特征。 它可能与严重的功能障碍、高服务利用率和不良临床结局相关。 这种症状可能与情绪刺激的神经处理中的潜在障碍有关。 情绪处理的神经生物学方面的研究的最新进展涉及在功能磁共振成像中将受试者暴露于情绪刺激。 这种类型的范式始终与皮质下和新皮质脑区的激活有关，这些脑区已知参与情绪体验和情绪信息处理。 情感性精神障碍患者在这些大脑区域中的几个区域表现出改变的反应，包括杏仁核，前扣带回，眶额和背外侧前额叶皮质。 在这些疾病中，杏仁核和前扣带皮层之间可能存在一种特别重要的情感调节功能关系。 相反，在BPD中，区域大脑对情绪刺激的激活模式还没有得到很好的研究。 本申请提出使用功能性磁共振成像来启动区域大脑对情绪刺激的反应的初步研究，预测BPD患者与正常对照相比，杏仁核和扣带皮层区域的激活将显示差异。 本研究的结果将用于以后检查这种假设的大脑功能障碍的症状（即诊断类别内）和BPD的诊断（即跨诊断类别）的临床特异性，并表征情感不稳定的额边缘模型中情绪处理障碍的时空动态。