NEURAL SUBSTRATE OF INTERPERSONAL DYSFUNCTION IN BORDERLINE PERSONALITY DISORDER

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该项目建议研究边缘人格障碍患者、目前患有严重抑郁障碍的患者和健康对照受试者的情绪信息处理和社会功能的潜在神经回路。我们建议通过观看面孔任务来检验情感反应，通过观察图片并对图片中描绘的人的经历进行评级来检验同理心，同时在事件相关任务设计中收集fMRI大胆反应。我们还将使用一种称为“事件应急记录”的方法，通过对社会互动的自然监测来表征所有受试者的社会行为和人际互动。我们将考察两个fMRI任务中的群体差异以及受试者之间的社会互动。交界性人格障碍(BPD)是一种以情感调节和冲动控制功能障碍为特征的致残障碍，常导致人际关系受损和适应不良的行为模式，包括攻击性和自毁行为。重度抑郁障碍与BPD相似，因为它涉及烦躁不安的情绪，但MDD患者往往不会有BPD中相同水平的人际关系症状。将患有MDD和BPD的人包括在内，将使我们能够将抑郁情绪的影响与更基本的边缘病理区分开来。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project proposes to examine the neural circuitry underlying components of emotional information processing and social functioning in individuals with borderline personality disorder, individuals with current Major Depressive Disorder and healthy control subjects. We propose to examine affective responsiveness through a face viewing task and empathy through observing pictures and rating the experience of the people depicted in the pictures, while gathering FMRI BOLD response in event-related task designs. We will also characterize the social behavior and interpersonal interactions of all subjects with a naturalistic monitoring of social interactions using a method called "Event Contingent Recording". We will examine group differences in the two fMRI tasks and in the social interactions of the subjects. Borderline Personality Disorder (BPD) is a disabling disorder characterized by dysfunction in affect regulation and impulse control often resulting in impaired interpersonal relationships and maladaptive behavioral patterns including aggression and self-destructive behavior. Major Depressive Disorder is similar to BPD in that it involves dysphoric affect, but individuals with MDD do not tend to have the same level of interpersonal symptoms that are seen in BPD. Including individuals with both MDD and BPD will allow us to tease apart the effect of depressed affect from more fundamental borderline pathology.