NEURAL SUBSTRATE OF INTERPERSONAL DYSFUNCTION IN BORDERLINE PERSONALITY DISORDER

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究旨在探讨边缘型人格障碍、重性抑郁障碍和健康对照者的情绪信息处理和社会功能的神经回路。我们建议通过观察图片和评价图片中描绘的人的经验，同时收集事件相关的任务设计的功能磁共振成像BOLD反应，通过面孔观察任务和共情检查情感反应。我们还将描述所有受试者的社会行为和人际交往，并使用一种称为“事件附带记录”的方法对社会交往进行自然监测。我们将研究两个功能磁共振成像任务和受试者的社会互动中的群体差异。边缘型人格障碍（BPD）是一种以情感调节和冲动控制功能障碍为特征的致残性障碍，通常导致人际关系受损和适应不良的行为模式，包括攻击性和自我毁灭行为。重度抑郁症与BPD类似，因为它涉及烦躁情绪，但患有MDD的个体往往没有BPD中所见的人际关系症状。包括MDD和BPD的个体将使我们能够将抑郁情绪的影响与更基本的边缘病理分开。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project proposes to examine the neural circuitry underlying components of emotional information processing and social functioning in individuals with borderline personality disorder, individuals with current Major Depressive Disorder and healthy control subjects. We propose to examine affective responsiveness through a face viewing task and empathy through observing pictures and rating the experience of the people depicted in the pictures, while gathering FMRI BOLD response in event-related task designs. We will also characterize the social behavior and interpersonal interactions of all subjects with a naturalistic monitoring of social interactions using a method called "Event Contingent Recording". We will examine group differences in the two fMRI tasks and in the social interactions of the subjects. Borderline Personality Disorder (BPD) is a disabling disorder characterized by dysfunction in affect regulation and impulse control often resulting in impaired interpersonal relationships and maladaptive behavioral patterns including aggression and self-destructive behavior. Major Depressive Disorder is similar to BPD in that it involves dysphoric affect, but individuals with MDD do not tend to have the same level of interpersonal symptoms that are seen in BPD. Including individuals with both MDD and BPD will allow us to tease apart the effect of depressed affect from more fundamental borderline pathology.