REGIONAL BRAIN CONTROL OF LABORATORY INDUCED AGGRESSION AS ASSESSED BY FDG PET

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定是研究者机构。冲动性攻击是人格障碍患者的一个重要临床问题，然而，它是一种难以研究的行为，因为它是一种间歇性行为。因此，有必要发展一个实验室评估人格障碍的冲动性攻击。在这项研究中，我们建议使用一个实验室测量的攻击，点减法攻击范式（PSAP），研究大脑激活模式的差异，使用18 FDG-PET人格障碍的受试者与冲动攻击和比较控制。我们建议在完成PSAP后对3名冲动型人格障碍受试者和3名非冲动型对照受试者进行成像。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Impulsive aggression is an important clinical problem in patients with personality disorders; however, it is a difficult behavior to study in that it is an intermittent behavior. It is, therefore, essential to develop a laboratory assessment of impulsive aggression in personality disorders. In this study we propose to use a laboratory measure of aggression, the Point Subtraction Aggression Paradigm (PSAP) to study differences in brain activation patterns using 18FDG- PET between personality disordered subjects with impulsive aggression and comparison controls. We propose to image 3 impulsive personality disorder subjects, and 3 non-impulsive comparison subjects after completion of the PSAP.