REGIONAL BRAIN CONTROL OF LABORATORY INDUCED AGGRESSION AS ASSESSED BY FDG PET

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Impulsive aggression is an important clinical problem in patients with personality disorders; however, it is a difficult behavior to study in that it is an intermittent behavior. It is, therefore, essential to develop a laboratory assessment of impulsive aggression in personality disorders. In this study we propose to use a laboratory measure of aggression, the Point Subtraction Aggression Paradigm (PSAP) to study differences in brain activation patterns using 18FDG- PET between personality disordered subjects with impulsive aggression and comparison controls. We propose to image 3 impulsive personality disorder subjects, and 3 non-impulsive comparison subjects after completion of the PSAP.