CHANGES IN PLASMA CONCENTRATIONS OF SUGARS AND SUGAR ALCOHOLS AFTER MILK FEEDING

喂奶后血浆中糖和糖醇浓度的变化

• 批准号: 7605134
• 负责人: FREDERICK C BATTAGLIA
• 金额: $ 5.33万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7605134
• 关键词: Blood flow; Carbohydrates; Computer Retrieval of Information on Scientific Projects Database; Energy Intake; Enrollment; Erythritol; Fetal Growth Retardation; Funding; Gestational Diabetes; Glucose; Glycerol; Grant; Hepatic; High Pressure Liquid Chromatography; Human Milk; Infant; Inositol; Institution; Intake; Mannose; Measurement; Milk; Mothers; Newborn Infant; Nutrient; Plasma; Pregnancy; Research; Research Personnel; Resources; Risk; Source; Sugar Alcohols; Umbilical Blood; United States National Institutes of Health; feeding; fetal; sugar; uptake

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study in feeding newborn infants will examine whether some of the sugars and sugar alcohols in breast milk and formula show evidence of a postprandial increase in concentration. After a single milk feeding, concentrations of glucose, inositol, glycerol, erythritol, sorbital and mannose will be examined over 90 minutes following the feeding. Only infants taking in full caloric intake by milk feedings will be enrolled in the studies. The intake of each sugar and sugar alcohol will be calculated from the volume of feed and the concentrations of the sugars and alcohols in the milk used for the feeding. HPLC will be used for the carbohydrate measurements. It is anticipated that the magnitude of the postprandial peak for any single carbohydrate will be a function of the volume of the feeding and the duration of the feeding. The study will also compare postprandial concentrations of the sugars and sugar alcohols in a group of healthy, term infants to a group of "high risk" infants who are born to mothers whose pregnancies were complicated by either pre-existing or gestational diabetes (IDM), or intrauterine growth restriction (IUGR). Umbilical blood flow has been demonstrated to be significantly reduced in IUGR pregnancies which, in turn, reduce fetal hepatic blood flow. Therefore, the hepatic uptake of nutrients after a feeding may be significantly compromised in these high risk infants.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 这项喂养新生儿的研究将检查母乳和配方奶粉中的某些糖和糖醇是否显示出餐后浓度增加的证据。单次喂奶后，将在喂奶后 90 分钟内检查葡萄糖、肌醇、甘油、赤藓糖醇、山梨糖醇和甘露糖的浓度。只有通过母乳喂养摄入全部热量的婴儿才会参加研究。每种糖和糖醇的摄入量将根据饲料量以及用于喂养的牛奶中糖和醇的浓度来计算。 HPLC 将用于碳水化合物测量。 预计任何单一碳水化合物的餐后峰值的大小将是饲喂量和饲喂持续时间的函数。 该研究还将比较一组健康足月婴儿和一组“高风险”婴儿的餐后糖和糖醇浓度，这些婴儿的母亲在怀孕期间患有既往糖尿病或妊娠期糖尿病（IDM）或宫内生长受限（IUGR）。 已证明 IUGR 妊娠时脐血流量显着减少，进而减少胎儿肝脏血流量。 因此，这些高危婴儿在喂养后肝脏对营养物质的吸收可能会受到显着影响。