THE EFFECT OF ALCOHOL DEPENDENCY AND ANXIETY ON BRAIN GABA LEVELS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 酒精中毒是一种多因素的障碍，与巨大的个人残疾和巨大的社会成本有关。酒精通过伽马-氨基丁酸(GABA)系统发挥某些作用(Ticku和Kulkarni，1988)。目前，酒精依赖或酒精依赖和焦虑症共病患者的人脑中GABA活体测量的信息很少。这项研究的目标是获得与健康对照组相比，最近戒酒并患有焦虑症和不患有焦虑症的酗酒者大脑GABA水平的先导数据。 具体目标：我们计划招募30名受试者，以获得24名男性和女性的完整数据，使用磁共振光谱成像(MRSI)来测量大脑GABA水平。受试者将被分为三组，每组8：1。)对照组，2)酒精依赖者和3)酒精依赖者和焦虑症患者。所有受试者将在4.0特斯拉(T)扫描仪上进行MRSI扫描，从中提取GABA光谱数据。假设一：与对照组相比，酒精依赖者的大脑GABA水平较低。假设二：有焦虑症的酒精依赖者的大脑GABA水平比无焦虑症的酒精依赖者低。假设二：与对照组相比，伴有和不伴有焦虑症的酒精依赖受试者的一氧化氮水平较低。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Alcoholism is a multifactorial disorder associated with tremendous individual disability and enormous cost to society. Alcohol exerts some of its effects through the gamma-aminobutyric acid (GABA) system (Ticku and Kulkarni 1988). Currently, there is a paucity of information in in vivo GABA measurements in the human brain of individuals with alcohol dependence or co-morbid alcohol dependence and anxiety disorders. The goal of this study is to ovtain pilot data on brain GABA levels in recently abstinent alcoholics with and without an anxiety disorder compared to healthy controls, Specific Aims: We plan to enroll 30 subjects in order to obtain complete data on 24 men and women using magneticresonance spectroscopic imaging (MRSI) to measure brain GABA levels. Subjects will be divided into three groups of 8: 1.) controls, 2) subjects with alcohol dependence and 3) subjects with alcohol dependence and an anxiety disorder. All subjects will have a MRSI scan on a 4.0 Tesla (T) scanner from which GABA spectral data will be extracted. Hypothesis I: Brain GABA levels will be lower in alcohol dependent subjects compared to controls. Hypothesis II: Brain GABA levels will be lower in alcohol dependent subjects with anxiety disorder compared to alcohol dependent without anxiety disorders. Hypothesis II: Alcohol dependent subjects with and without comorbid anxiety disorder will have lower nitric oxide levels than controls.