THE EFFECT OF ALCOHOL DEPENDENCY AND ANXIETY ON BRAIN GABA LEVELS

酒精依赖和焦虑对大脑 GABA 水平的影响

• 批准号: 7606284
• 负责人: Chris Conway Streeter
• 金额: $ 0.07万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-01-03 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606284
• 关键词: Alcohol dependence; Alcoholism; Alcohols; Anxiety; Anxiety Disorders; Brain; Computer Retrieval of Information on Scientific Projects Database; Data; Disease; Enrollment; Funding; Goals; Grant; Human; Individual; Institution; Measurement; Measures; Nitric Oxide; Research; Research Personnel; Resources; Scanning; Societies; Source; System; United States National Institutes of Health; Woman; cost; disability; gamma-Aminobutyric Acid; in vivo; men; problem drinker; spectroscopic imaging

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Alcoholism is a multifactorial disorder associated with tremendous individual disability and enormous cost to society. Alcohol exerts some of its effects through the gamma-aminobutyric acid (GABA) system (Ticku and Kulkarni 1988). Currently, there is a paucity of information in in vivo GABA measurements in the human brain of individuals with alcohol dependence or co-morbid alcohol dependence and anxiety disorders. The goal of this study is to ovtain pilot data on brain GABA levels in recently abstinent alcoholics with and without an anxiety disorder compared to healthy controls, Specific Aims: We plan to enroll 30 subjects in order to obtain complete data on 24 men and women using magneticresonance spectroscopic imaging (MRSI) to measure brain GABA levels. Subjects will be divided into three groups of 8: 1.) controls, 2) subjects with alcohol dependence and 3) subjects with alcohol dependence and an anxiety disorder. All subjects will have a MRSI scan on a 4.0 Tesla (T) scanner from which GABA spectral data will be extracted. Hypothesis I: Brain GABA levels will be lower in alcohol dependent subjects compared to controls. Hypothesis II: Brain GABA levels will be lower in alcohol dependent subjects with anxiety disorder compared to alcohol dependent without anxiety disorders. Hypothesis II: Alcohol dependent subjects with and without comorbid anxiety disorder will have lower nitric oxide levels than controls.

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