BRAIN LITHIUM LEVELS IN BIPOLAR INDIVIDUALS

双相情感障碍患者的脑锂水平

• 批准号: 7606225
• 负责人: Chris Conway Streeter
• 金额: $ 0.45万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-01-03 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606225
• 关键词: African; Brain; Caring; Computer Retrieval of Information on Scientific Projects Database; Confounding Factors (Epidemiology); Data Analyses; Dose; Enrollment; Erythrocytes; European; Funding; Grant; Guidelines; Individual; Institution; Lithium; Lithium Compounds; Magnetic Resonance Spectroscopy; Measurement; Measures; Mental Health; Preparation; Psychiatric therapeutic procedure; Recording of previous events; Research; Research Personnel; Research Project Grants; Resources; Serum; Source; United States National Institutes of Health; improved; racial/ethnic difference; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project will compare serum lithium levels to brain lithium levels in subjects with histories of bipolar illness on a stable dose of lithium compounds. Brain lithium levels will be measured using Lithium-7 magnetic resonance spectroscopy (7LiMRS). The principal aim of this study is to establish the utility of 7LiMRS in determining differences in brain-to-serum lithium ratios in Blacks of African descent compared to Whites of Western European descent. Since brain lithium may be a critical determinant of treatment response, measurement of brain lithium by 7LiMRS may ultimately be clinically important for guiding rational therapy with this agent. This research project is directed at improving mental health care for Blacks of African descent treated with lithium. Despite abundant empirical evidence that Na-Li countertransport is decreased in the erythrocytes of Blacks of African descent, established guidelines for lithium treatment do not consider the confounding variable of racial variability in erythrocyte Na-Li countertransport. This is an exciting study, as it will improve our ability to provide psychiatric care in a manner sensitive to racial/ethnic differences. This study was approved in 2001. We have been enrolling subjects for 4 years and are near the end of enrollment. It is anticipate that we will be analyzing data for the next two years. Four hundred potential subjects will be screened to identify 25 Black subjects of African descent and 25 White subjects of Western European descent who are euthymic and on stable doses of lithium preparations for the treatment of bipolar or schizoaffective illness.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本项目将比较有双相情感障碍病史的受试者接受稳定剂量锂化合物治疗时的血清锂水平和脑锂水平。将使用锂-7磁共振波谱（7 LiMRS）测量脑锂水平。本研究的主要目的是建立7 LiMRS的效用，在确定脑血清锂比在非洲裔黑人相比，西欧裔白人的差异。由于脑锂可能是治疗反应的关键决定因素，因此通过7 LiMRS测量脑锂最终可能对于指导该药物的合理治疗具有临床重要意义。该研究项目旨在改善接受锂治疗的非洲裔黑人的心理保健。尽管有大量的经验证据表明，在非洲裔黑人的红细胞中，钠-锂反向转运减少，但锂治疗的既定指南并未考虑红细胞钠-锂反向转运中种族变异性的混杂变量。这是一项令人兴奋的研究，因为它将提高我们对种族/民族差异敏感的精神病护理的能力。这项研究于2001年获得批准。我们已经招募了4年的受试者，并接近招募结束。预计我们将分析未来两年的数据。将筛选400例潜在受试者，以确定25例非裔黑人受试者和25例西欧裔白色受试者，这些受试者的胸腺功能正常，并接受稳定剂量的锂制剂治疗双相或情感障碍疾病。