AGING AND ALZHEIMER'S DISEASE BIOSAMPLE REPOSITORY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 波士顿大学阿尔茨海默病中心(BU ADC)多年来一直参与多项临床研究，着眼于衰老和与年龄相关的记忆障碍，包括阿尔茨海默病。这些研究的参与者的动机是希望帮助降低痴呆症的发病率和发病率。绝大多数参与者愿意为这一事业献血，包括DNA样本。与此同时，许多研究人员正在寻找血液成分(如DNA、血清/血浆)中的疾病风险标记物。 波士顿大学老龄化和阿尔茨海默病生物样本库被设想为一种将研究人员和参与者的利益聚集在一起的方式，对两组人都是最有利的。在波士顿大学设立一个储存库，将允许参与者在一个研究领域中为更多的研究做出贡献，而这些研究是他们明确表示愿意做出贡献的。然后，研究人员将有一个可用的生物成分池来访问。此外，波士顿大学ADC的未来研究工作将有一个既定的协议和生物样本的存储，从而激励人们在衰老和记忆障碍领域进行更具创造性的研究。这些目标与NIA资助的波士顿大学阿尔茨海默病中心的要求以及NIA和NIH声明的共享政策和偏好是一致的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Boston University Alzheimer's Disease Center (BU ADC) has for many years been involved in multiple clinical research studies looking at aging and age-related memory disorders, including Alzheimer's disease. The participants in these studies are motivated by a desire to help decrease the incidence and morbidity of dementia. The vast majority of participants are willing to donate blood, including DNA samples, towards this cause. At the same time, many researchers are looking for markers of disease risk in blood components (e.g., DNA, serum/plasma). The Boston University Aging and Alzheimer's Disease BioSample Repository was conceived as a way of bringing together the interests of researchers and participants in a manner that would be optimally beneficial to both groups. A repository at BU would allow participants to contribute to a greater number of studies in a research area in which they have a declared intention to contribute. Researchers would then have a pool of available biological components to access. Furthermore, future research efforts at the BU ADC will have an established protocol and storage for biological samples, creating an incentive to pursue more creative research in the area of aging and memory disorders. These goals are consistent with the requirements of the NIA-funded Alzheimer's Disease Center at Boston University and with stated sharing policies and preferences of NIA and NIH.