ARGININE SUPPLEMENTATION IN SICKLE CELL ANEMIA-PHYSIOLOGICAL AND PROPHYLATIC
ARGININE SUPPLEMENTATION IN SICKLE CELL ANEMIA-PHYSIOLOGICAL AND PROPHYLATIC
批准号:
7606261
负责人:
Lillian E McMahon
金额:
$0.1万
依托单位国家:
美国
项目类别:
财政年份:
2007
资助国家:
美国
项目状态:
已结题
起止时间:
2007-01-03 至 2007-11-30
关键词:
AdolescentAdultAffectAmino AcidsAnemiaArginineChildComputer Retrieval of Information on Scientific Projects DatabaseDailyDiseaseDoseErythrocytesFundingGrantInfectionInheritedInstitutionInvestigational DrugsNitric OxideOral cavityOrganPainPhysiologicalPlacebosRandomizedRecurrenceResearchResearch PersonnelResourcesSickle Cell AnemiaSourceSupplementationUnited States National Institutes of HealthWeekblood vessel occlusionbody systemdaydouble-blind placebo controlled trial
中文摘要
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Sickle cell disease is a serious inherited disease of the red blood cells resultiing in sever anemia and episodes of occlusion of the blood vessels. This vaso-occlusion affects every organ system in the body and results in recurrent episodes of pain, overwhelming infections and progressive organ damage. Nitric oxide is a substance produced by arginine and has many functions that could impact favorably in vaso-occlusion in sickle cell disease. Arginine is an aminoacid that has been shown to raise nitric oxide and have benificial results in subjects with sickle cell disease, and will help to determine if daily arginine is a benificial investigational drug for subjects with sickle cell disease. This study is a double-blind, placebo-controlled trial in which eligible subjects (children, adolescents, and adults) with sickle cell disease will receive either arginine or placebo by mouth during 12 weeks. Subjects will be randomized to recieve placebo or one of two doses of arginine (0.04g/kg/day).
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会议论文
NEUROPSYCHOLOGICAL DYSFUNCTION AND NEUROIMAGING ABNORMALITIES IN SCD
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批准号:7606262
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项目类别:
-
资助金额:$0.73万
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财政年份:2007
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负责人:Lillian E McMahon
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依托单位:
Boston Sickle Cell Research Consortium
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批准号:7065887
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项目类别:
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资助金额:$15.58万
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财政年份:2006
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负责人:Lillian E McMahon
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依托单位:
Boston Sickle Cell Research Consortium
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批准号:7227738
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项目类别:
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资助金额:$15.49万
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财政年份:2006
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负责人:Lillian E McMahon
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依托单位:
Boston Sickle Cell Research Consortium
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批准号:7414377
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项目类别:
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资助金额:$35.11万
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财政年份:2006
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负责人:Lillian E McMahon
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依托单位:
NEUROPSYCHOLOGICAL DYSFUNCTION AND NEUROIMAGING ABNROMALITIES IN SCD
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批准号:7379519
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项目类别:
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资助金额:$0.35万
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财政年份:2005
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负责人:Lillian E McMahon
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依托单位:
ARGININE SUPPLEMENTATION IN SICKLE CELL ANEMIA-PHYSIOLOGICAL AND PROPHYLATIC
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批准号:7379517
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项目类别:
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资助金额:$0.69万
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财政年份:2005
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负责人:Lillian E McMahon
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依托单位:
CORE--Patient Services Core
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批准号:6900244
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项目类别:
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资助金额:$7.17万
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财政年份:2004
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负责人:Lillian E McMahon
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依托单位:
CORE--TESTING
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批准号:6325891
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项目类别:
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资助金额:$26.66万
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财政年份:2000
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负责人:Lillian E McMahon
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依托单位:
CORE--EDUCATION AND COUNSELING
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批准号:6325894
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项目类别:
-
资助金额:$26.66万
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财政年份:2000
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负责人:Lillian E McMahon
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依托单位:
CORE--CLINICAL
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批准号:6325893
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项目类别:
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资助金额:$26.66万
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财政年份:2000
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负责人:Lillian E McMahon
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依托单位:
CORE--EDUCATION AND COUNSELING
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批准号:6109391
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项目类别:
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资助金额:$26.66万
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财政年份:1999
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负责人:Lillian E McMahon
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依托单位:
CORE--TESTING
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批准号:6109388
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项目类别:
-
资助金额:$26.66万
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财政年份:1999
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负责人:Lillian E McMahon
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依托单位:
CORE--CLINICAL
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批准号:6109390
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项目类别:
-
资助金额:$26.66万
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财政年份:1999
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负责人:Lillian E McMahon
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依托单位:
CORE--EDUCATION AND COUNSELING
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批准号:6272523
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项目类别:
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资助金额:$27.76万
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财政年份:1998
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负责人:Lillian E McMahon
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依托单位:
CORE--CLINICAL
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批准号:6272522
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项目类别:
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资助金额:$27.76万
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财政年份:1998
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负责人:Lillian E McMahon
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依托单位:
CORE--TESTING
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批准号:6272520
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项目类别:
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资助金额:$27.76万
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财政年份:1998
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负责人:Lillian E McMahon
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依托单位:
CORE DIAGNOSTIC LAB--TESTING
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批准号:6241525
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项目类别:
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资助金额:$47.63万
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财政年份:1997
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负责人:Lillian E McMahon
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依托单位:
COMPREHENSIVE SICKLE CELL CENTER
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批准号:3108418
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项目类别:
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资助金额:$4.25万
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财政年份:1991
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负责人:Lillian E McMahon
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依托单位:
SMALL INSTRUMENTATION PROGRAM
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批准号:3522792
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项目类别:
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资助金额:$1.42万
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财政年份:1988
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负责人:Lillian E McMahon
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依托单位:
COMPREHENSIVE SICKLE CELL CENTER
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批准号:3108424
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项目类别:
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资助金额:$170.72万
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财政年份:1977
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负责人:Lillian E McMahon
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依托单位:
海外基金