NEUROPSYCHOLOGICAL DYSFUNCTION AND NEUROIMAGING ABNORMALITIES IN SCD

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 这项研究的目的是确定镰状细胞病成年人的记忆和注意力问题的程度。没有经历过中风或其他脑损伤的成年人将被要求参加这项研究。本研究还将评价这些事件或状况与MRI异常之间的联系。这些发现将与具有类似背景的健康人进行比较。对于一些参与者来说，测试将显示记忆和注意力问题的证据，这可能是由大多数镰状细胞病患者的贫血引起的。纠正贫血与一些非镰状细胞患者的记忆力和注意力有关。该研究的第二部分将涉及在完成神经心理学测试和MRI的受试者中治疗贫血6个月，以评估输血对记忆和注意力的影响。第二个研究阶段是随机对照临床试验。该研究治疗组的患者将接受6个月的输血，作为改善记忆力的潜在治疗。非干预组患者将不接受输血治疗。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this research study is to determine the extent of memory and attention problems in adults with sickle cell disease. Adults who have not experienced a stroke or other brain damage will be asked to join the study. The study will also evaluate the link between these events or conditions and abnormal MRI. These findings will be compared to healthy people with similar backgrounds. For some participants, testing will show evidence of problems with memory and attention, potentially caused by the anemia that occurs among most patients with sickle cell disease. Correcting anemia has been linked in some non-sickle cell patients with better memory and attention. A second part of the study will involve treating anemia for six months in a subset of subjects who have completed the neuropsychological testing and MRI to assess the effect of trnasfusion on memory and attention. This second study phase is a randomized controlled clinical trial. Patients in the treatment arm of the study will receive six monthly transfusions as a potential treatment to improve memory. Patients in the non-intervention group will receive no transfusion therapy.