PACTG 1025

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 研究中心，而研究中心不一定是研究者所在的机构。 PACTG P1025是一项前瞻性队列研究，提供了一个框架，用于收集和评价人类免疫缺陷病毒（HIV）感染的孕妇和产后妇女及其婴儿的数据和储存标本。 本研究的主要目的是：评估干预措施的有效性（如抗逆转录病毒疗法和分娩方式），以预防艾滋病毒的垂直传播和/或妇女健康;评估干预措施的物质和婴儿安全性（如抗逆转录病毒疗法和分娩方式）用于妇女健康和/或预防艾滋病毒垂直传播;为密集的子研究提供框架和样本库（如PACTG P1026、妊娠期药代动力学）、New Works概念表（NWCS）和数据分析概念表（DACS），旨在进一步阐明艾滋病毒垂直传播的风险因素和机制，以及影响母婴结局的因素;评估感染艾滋病毒的孕妇在怀孕期间和产后坚持抗逆转录病毒治疗的情况及其对妇女健康和垂直传播的影响，并评估婴儿坚持化疗的情况。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. PACTG P1025 is a prospective cohort study that provides a framework for collection and evaluation of data and collection of repository specimens from Human Immunodeficiency Virus (HIV)-infected pregnant and postpartum women and their infants. The primary objectives of this study are: to assess the effectiveness of interventions (e.g. antiretroviral therapy and mode of delivery) prescribed for prevention of vertical transmission of HIV and/or for women's health; to assess material and infant safety of interventions (e.g. Antiretroviral Therapy (ART) and mode of delivery) prescribed for women's health and/or for prevention of vertical transmission of HIV; to provide a framework and specimen repository for intensive substudies (such as PACTG P1026s, pharmacokinetics in pregnancy), New Works Concept Sheets (NWCS) and Data Analysis Concept Sheets (DACS) that aim to further elucidate risk factors for and mechanisms of vertical transmission of HIV, as well as factors that affect maternal and infant outcomes; to assess adherence to ART among HIV-infected pregnant women during pregnancy and postpartum and its impact on women's health and vertical transmission, and to assess adherence to chemoprophylaxsis in infants.