ORAL CANDIDA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 口腔念珠菌病可能是与免疫功能受损的宿主有关的最常见的机会性感染。抵抗念珠菌的最重要的免疫细胞类型是中性粒细胞(PMN)。虽然这些细胞被认为在抵抗和根除真菌方面很重要，但这些功能的表达需要被称为细胞因子的可溶性蛋白质激活。在免疫受损的宿主中，这些分子更有可能来自非免疫来源的细胞，如上皮细胞。本研究的目的是检测口腔上皮细胞分泌的细胞因子对中性粒细胞抗真菌功能的激活作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Oral candidiasis is perhaps the most frequent opportunistic infection associated with an immunocompromised host. The most important immune cell type in the defense against Candida is the neutrophil (PMN). Although these cells are considered important in the resistance to and eradication of fungi, expression of these functions requires activation by soluble proteins known as cytokines. In the immunocompromised host these molecules are more likely to be derived from cells of non-immune origin, such as epithelial cells. The purpose of this study is to test the activation of neutrophil anti-fungal functions in response to cytokines secreted by oral epithelial cells.