ORAL CANDIDA

口腔念珠菌

• 批准号: 7607610
• 负责人: Anna I Dongari-Bagtzoglou
• 金额: $ 0.98万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607610
• 关键词: Antifungal Agents; Candida; Cells; Computer Retrieval of Information on Scientific Projects Database; Epithelial Cells; Funding; Grant; Immune; Immunocompromised Host; Institution; Neutrophil Activation; Opportunistic Infections; Oral; Oral candidiasis; Proteins; Purpose; Research; Research Personnel; Resistance; Resources; Source; Testing; United States National Institutes of Health; cell type; cytokine; fungus; neutrophil; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Oral candidiasis is perhaps the most frequent opportunistic infection associated with an immunocompromised host. The most important immune cell type in the defense against Candida is the neutrophil (PMN). Although these cells are considered important in the resistance to and eradication of fungi, expression of these functions requires activation by soluble proteins known as cytokines. In the immunocompromised host these molecules are more likely to be derived from cells of non-immune origin, such as epithelial cells. The purpose of this study is to test the activation of neutrophil anti-fungal functions in response to cytokines secreted by oral epithelial cells.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 口腔念珠菌病可能是最常见的机会性感染与免疫功能低下的主机。在防御念珠菌中最重要的免疫细胞类型是中性粒细胞（PMN）。虽然这些细胞被认为在抵抗和根除真菌中很重要，但这些功能的表达需要被称为细胞因子的可溶性蛋白质激活。在免疫受损的宿主中，这些分子更可能来源于非免疫来源的细胞，例如上皮细胞。本研究的目的是测试中性粒细胞的抗真菌功能的激活响应于由口腔上皮细胞分泌的细胞因子。