ORAL CANDIDA

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 口腔念珠菌病可能是最常见的机会性感染与免疫功能低下的主机。在防御念珠菌中最重要的免疫细胞类型是中性粒细胞（PMN）。虽然这些细胞被认为在抵抗和根除真菌中很重要，但这些功能的表达需要被称为细胞因子的可溶性蛋白质激活。在免疫受损的宿主中，这些分子更可能来源于非免疫来源的细胞，例如上皮细胞。本研究的目的是测试中性粒细胞的抗真菌功能的激活响应于由口腔上皮细胞分泌的细胞因子。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Oral candidiasis is perhaps the most frequent opportunistic infection associated with an immunocompromised host. The most important immune cell type in the defense against Candida is the neutrophil (PMN). Although these cells are considered important in the resistance to and eradication of fungi, expression of these functions requires activation by soluble proteins known as cytokines. In the immunocompromised host these molecules are more likely to be derived from cells of non-immune origin, such as epithelial cells. The purpose of this study is to test the activation of neutrophil anti-fungal functions in response to cytokines secreted by oral epithelial cells.