DYNAMIC MECHANISMS OF PAIN MODULATION-SYSTEMIC CLONIDINE

疼痛调节的动态机制——系统性可乐定

• 批准号: 7607714
• 负责人: Robert C Coghill
• 金额: $ 1.99万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607714
• 关键词: Absence of pain sensation; Analgesics; Brain; Clinical Research; Clonidine; Computer Retrieval of Information on Scientific Projects Database; Condition; Dose; Esthesia; Forearm; Funding; Grant; Gray unit of radiation dose; Heating; Human; Human body; Institution; Learning; Measures; Nerve; Oral; Pain; Pain-Free; Participant; Pharmaceutical Preparations; Placebos; Procedures; Process; Range; Research; Research Personnel; Resources; Series; Site; Source; Spinal Cord; Training; United States National Institutes of Health; Visit; Week; Work; chronic pain; experience; novel strategies; prescription document; prescription procedure; research study; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We all have experienced pain, however, very little is known about exactly what goes on in the human body while we feel pain. By applying different combinations of painful sensations under different conditions, and measuring the responses to them, we can make indirect observations as to how the nervous system (brain, spinal cord, and nerves) processes pain. By finding out how different aspects of pain feel, we hope to get a better understanding of how humans experience pain and what new approaches we may take to treat pain. A total of 20 people will be involved as subjects for the research study. This total will include 20 normal healthy (pain-free) subjects who will participate at this research site in the Coghill Lab, Gray building, room 4087 and at the General Clinical Research Center (GCRC). All participants will be without chronic pain, not taking analgesics (pain medications) regularly and will not have taken any prescription pain medications for 2 weeks before the study. The study procedures will require 4 visits. This will include a training period to learn how the heat probe works and how to estimate the pain using the VAS. The subject will be given a series of thermal stimulations ranging from 35 degrees C to 51 degrees C on his/her non-dominant forearm during each of the visits. A single oral dose of clonidine 900 ug/placebo will be administered on visit 1 or visit 3 to help delineate the mechanism that supports the phenomenon of offset analgesia.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们都经历过疼痛，然而，很少有人知道当我们感到疼痛时人体内到底发生了什么。通过在不同条件下应用不同的疼痛感觉组合，并测量对它们的反应，我们可以间接观察神经系统（大脑，脊髓和神经）如何处理疼痛。通过了解疼痛的不同方面，我们希望更好地了解人类如何体验疼痛以及我们可以采取哪些新方法来治疗疼痛。 共有20人将作为研究对象参与研究。这一总数将包括20例正常健康（无疼痛）受试者，他们将在本研究中心（Coghill Lab，Gray大楼，4087室）和综合临床研究中心（GCRC）参加研究。所有受试者均无慢性疼痛，未定期服用镇痛药（止痛药），并且在研究前2周内未服用任何处方止痛药。 研究程序将需要4次访视。这将包括一个培训期，以了解热探头如何工作以及如何使用VAS估计疼痛。在每次访视期间，受试者的非优势前臂将接受一系列温度范围为35 ℃至51 ℃的热刺激。将在访视1或访视3时给予单次口服可乐定900 ug/安慰剂，以帮助描述支持抵消镇痛现象的机制。