DYNAMIC MECHANISMS OF PAIN MODULATION-SYSTEMIC CLONIDINE
疼痛调节的动态机制——系统性可乐定
基本信息
- 批准号:7607714
- 负责人:
- 金额:$ 1.99万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2007
- 资助国家:美国
- 起止时间:2007-03-01 至 2008-02-29
- 项目状态:已结题
- 来源:
- 关键词:Absence of pain sensationAnalgesicsBrainClinical ResearchClonidineComputer Retrieval of Information on Scientific Projects DatabaseConditionDoseEsthesiaForearmFundingGrantGray unit of radiation doseHeatingHumanHuman bodyInstitutionLearningMeasuresNerveOralPainPain-FreeParticipantPharmaceutical PreparationsPlacebosProceduresProcessRangeResearchResearch PersonnelResourcesSeriesSiteSourceSpinal CordTrainingUnited States National Institutes of HealthVisitWeekWorkchronic painexperiencenovel strategiesprescription documentprescription procedureresearch studyresponse
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
We all have experienced pain, however, very little is known about exactly what goes on in the human body while we feel pain. By applying different combinations of painful sensations under different conditions, and measuring the responses to them, we can make indirect observations as to how the nervous system (brain, spinal cord, and nerves) processes pain. By finding out how different aspects of pain feel, we hope to get a better understanding of how humans experience pain and what new approaches we may take to treat pain.
A total of 20 people will be involved as subjects for the research study. This total will include 20 normal healthy (pain-free) subjects who will participate at this research site in the Coghill Lab, Gray building, room 4087 and at the General Clinical Research Center (GCRC). All participants will be without chronic pain, not taking analgesics (pain medications) regularly and will not have taken any prescription pain medications for 2 weeks before the study.
The study procedures will require 4 visits. This will include a training period to learn how the heat probe works and how to estimate the pain using the VAS. The subject will be given a series of thermal stimulations ranging from 35 degrees C to 51 degrees C on his/her non-dominant forearm during each of the visits. A single oral dose of clonidine 900 ug/placebo will be administered on visit 1 or visit 3 to help delineate the mechanism that supports the phenomenon of offset analgesia.
这个子项目是许多研究子项目中的一个
由NIH/NCRR资助的中心赠款提供的资源。子项目和
研究者(PI)可能从另一个NIH来源获得了主要资金,
因此可以在其他CRISP条目中表示。所列机构为
研究中心,而研究中心不一定是研究者所在的机构。
我们都经历过疼痛,然而,很少有人知道当我们感到疼痛时人体内到底发生了什么。通过在不同条件下应用不同的疼痛感觉组合,并测量对它们的反应,我们可以间接观察神经系统(大脑,脊髓和神经)如何处理疼痛。通过了解疼痛的不同方面,我们希望更好地了解人类如何体验疼痛以及我们可以采取哪些新方法来治疗疼痛。
共有20人将作为研究对象参与研究。这一总数将包括20例正常健康(无疼痛)受试者,他们将在本研究中心(Coghill Lab,Gray大楼,4087室)和综合临床研究中心(GCRC)参加研究。所有受试者均无慢性疼痛,未定期服用镇痛药(止痛药),并且在研究前2周内未服用任何处方止痛药。
研究程序将需要4次访视。这将包括一个培训期,以了解热探头如何工作以及如何使用VAS估计疼痛。在每次访视期间,受试者的非优势前臂将接受一系列温度范围为35 ℃至51 ℃的热刺激。将在访视1或访视3时给予单次口服可乐定900 ug/安慰剂,以帮助描述支持抵消镇痛现象的机制。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Robert C Coghill其他文献
Robert C Coghill的其他文献
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{{ truncateString('Robert C Coghill', 18)}}的其他基金
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Identifying neural pathophysiology in juvenile fibromyalgia
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Dissecting Neural Mechanisms Supporting Mind and Body Approaches to Pain Reduction in Youth with Migraine
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9906854 - 财政年份:2019
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Dissecting Neural Mechanisms Supporting Mind and Body Approaches to Pain Reduction in Youth with Migraine
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Distinct Mechanisms of Cognitive Behavioral Therapy Effects in Youth with Migraine: Insights from Neuroimaging and Quantitative Sensory Testing (The How and Why Youth with Headaches Get Better Study)
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- 批准号:
10395448 - 财政年份:2018
- 资助金额:
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Distinct Mechanisms of Cognitive Behavioral Therapy Effects in Youth with Migraine: Insights from Neuroimaging and Quantitative Sensory Testing (The How and Why Youth with Headaches Get Better Study)
认知行为治疗对偏头痛青少年的影响的独特机制:来自神经影像学和定量感官测试的见解(头痛青少年如何以及为何得到更好的研究)
- 批准号:
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Brain Mechanisms Supporting Individual Differences in Pain
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- 批准号:
9258510 - 财政年份:2015
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Brain Mechanisms Supporting Individual Differences in Pain
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- 批准号:
8818530 - 财政年份:2015
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Brain Mechanisms Supporting the Modulation of Pain by Meditation and Placebo
支持通过冥想和安慰剂调节疼痛的大脑机制
- 批准号:
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