MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA)

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Multi-Ethnic Study of Atherosclerosis (MESA) is a 10-year NHLBI-funded multi-center study of subclinical cardiovascular disease (disease detected non-invasively before it has produced signs and symptoms). The overall goal of this study is to identify characteristics of persons with subclinical atherosclerosis that predict progression to clinical heart disease events. The specific aims of this study are: to determine characteristics related to clinical heart disease; to identify new measures of subclinical disease; and to develop methods for identifying the highest risk asymptomatic persons for application in future screening and intervention studies. We will accomplish these aims by participating as a field center in a collaborative, multi-center, cohort study of persons ages 45-84 years without evidence of clinical cardiovascular disease at baseline. We are currently participating in the collaborative protocol development and the pilot study phase, during the first 18 months of the study. We will begin recruiting 1,100 Forsyth County adults at the WFUSM field center (including 50% African Americans) beginning in the Summer of 2000. Participants will be evaluated for subclinical cardiovascular disease using a number of technologic procedures. These data will be important to better design future clinical and population-based intervention programs to further reduce the burden of cardiovascular disease in the United States.