CHS research resources for the cardiovascular health of older adults

 描述(由申请人提供)：本申请寻求心血管健康研究(CHS)的基础设施支持。NHLBI已经改变了对其合同资助的队列研究的支持方法。在弗雷明翰，动脉粥样硬化多种族研究(MESA)和社区动脉粥样硬化风险(ARIC)，有限的合同续签将包括短期内的基础设施支持，但其中将包括资金，以便在且仅当他们的调查人员在同行审查中成功竞争拨款申请，以进行至少一个主要检查部分时，才能将参与者带到诊所。最终，即使是对这些群体的基础设施支持也将需要同行审查，就像目前对社区卫生服务所做的那样。这个 NHLBI流行病学工作组推荐了一个类似于国家癌症研究所已经使用的竞争性模型(NCI，PAR-14-160，癌症队列的核心基础设施和方法研究)。然而，目前NHLBI缺乏一个类似NCI的基础设施赠款同行审查机制，因此CHS的唯一选择是寻求同行审查的R01资金，即使基础设施支持的类型不同于假设检验赠款。基础设施的目的是创建研究资源；对于队列研究，主要活动包括与参与者接触、收集新数据、对活动采取后续行动、质量控制、数据和生物标本管理、研究管理和交流。这些目标都不涉及对假设的检验。正如NCI PAR-14-160所指出的那样，重点是最大限度地满足未来科学需求的潜力、使群体能够解决尖端研究问题以及促进科学合作的活动。也许基础设施赠款的主要挑战是不能证明潜在用户的高需求水平。这项赠款申请的两个主要目标是：1)将社区卫生服务转变为老年人心血管健康的研究资源；2)采用创新的方法，确保这一基础设施的有效利用。对于第一个目标，研究资源的目的是支持：1)CHS协调中心，其各种数据库，及其数据管理和行政活动；2)CHS生物库；3)一年两次的电话呼叫，以收集新的信息；以及4)心血管结果和总死亡率的事件数据收集。第二个目标是促进这些研究资源的使用。为实现这一目标，目标是：1)为8个社区卫生服务工作组(WG)提供有限和有重点的支持，以使用社区卫生服务数据并开发赠款申请，以解决新的问题和假设；2)支持有指导的访问社区卫生服务数据和标本；以及3)向所有研究人员提供社区卫生服务数据、新事件数据和辅助研究机会。每年，WGS将招募8-16名新合作者，发表30-54篇论文，并产生6-12项新的辅助研究提案。CHS的发现将对开发新的心血管疾病预防策略和改善美国老年人的健康至关重要。

 DESCRIPTION (provided by applicant): This application seeks infrastructure support for the Cardiovascular Health Study (CHS). The NHLBI has changed the methods of support for its contract-funded cohort studies. In Framingham, the Multi-Ethnic Study of Atherosclerosis (MESA) and the Atherosclerosis Risk in Communities (ARIC), limited contract renewals will include infrastructure support in the near-term, but they will include funds to bring participants into the clinics if and only if their investigators successfully compete at peer review for grant applications to conduct at least one major examination component. Eventually, even infrastructure support for these cohorts will require peer review as it currently does for CHS. The NHLBI Epidemiology Working Group recommends a competitive model similar to the one already used by the National Cancer Institute (NCI, PAR-14-160, Core Infrastructure and Methodological Research for Cancer Cohorts). At this time, however, the NHLBI lacks an NCI-like mechanism for the peer review of infrastructure grants, so the only option for CHS is to seek peer-reviewed R01 funding even though the genre of infrastructure support differs from that of hypothesis-testing grants. The purpose of infrastructure is to create a research resource; and for a cohort study, the major activities include contact with participants, collection of new data, follow-up for events, quality control, management of data and biospecimens, study administration and communications. None of these aims involves the test of an hypothesis. As the NCI PAR-14-160 indicates, the focus is on activities that will maximize the potential to respond to future scientific needs; enable cohorts to address cutting edge research questions; and facilitate scientific collaboration. Perhaps the major challenge for infrastructure grants is t demonstrate a high level of demand among the potential users. The two main goals of this grant application are: 1) to transform CHS into a research resource for the cardiovascular health of older adults; and 2) to deploy innovative approaches to assure the productive use of this infrastructure. For the first goal, the research-resource aims are to support: 1) the CHS Coordinating Center, its various databases, and its data-management and administrative activities; 2) the CHS Biorepository; 3) biannual telephone calls to collect new information; and 4) events data collection for the cardiovascular outcomes and total mortality. The second goal is to promote the use of these research resources. For this goal, the aims are: 1) to provide limited and focused support for 8 CHS Working Groups (WGs) to use CHS data and develop grant applications to address new questions and hypotheses; 2) to support mentored access to CHS data and specimens; and 3) to make CHS data, new events data, and ancillary-study opportunities available to all investigators. In each year, the WGs will recruit 8-16 new collaborators, publish 30-54 papers, and generate 6-12 new ancillary study proposals. The findings from CHS will be vital for the developing novel CVD preventive strategies and for improving the health of older adults in the US.