REFERENCE VALUES FOR BONE MASS AND DENSITY OF LUMBAR SPINE

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Dual energy x-ray absorptiometry (DXA) is widely used to assess bone mass and density in children with chronic illnesses. Knowledge of the normal distribution of values of bone mineral content (BMC) and bone mineral density (BMD) in healthy children is necessary in order to evaluate bone health in children with chronic disease. The aim of this project is to obtain a set of reference data on BMC and BMD of the lumbar spine from children between the ages of 6 to 36 months. Two hundred infants and children, 6-36 months of age, will be recruited for this cross sectional study. The Hologic QDR 4500 densitometer will be used to obtain measurements of BMC and BMD of the lumbar spine. Body weight and length also will be measured. BMC and BMD reference curves that describe the BMC and BMD at specific percentiles for age will be generated.