Clinical-Component
Clinical-Component
批准号:
10442030
负责人:
Heidi J Kalkwarf
金额:
$5.92万
依托单位国家:
美国
项目类别:
财政年份:
2007
资助国家:
美国
项目状态:
未结题
起止时间:
2007-08-01 至 2027-05-31
关键词:
AffectAgeAreaAttentionAwardBasic ScienceBiological ProcessBiometryBiopsyCenter for Translational Science ActivitiesChildChildhoodClinicalClinical ResearchClinical TrialsComplexConsultationsCustomDataData AnalysesDatabasesDevelopmentDigestive System DisordersDiseaseEnsureFosteringFundingGenomicsGoalsGrowthHealthHourHumanInfrastructureInstitutional Review BoardsInvestigationLaboratoriesLaboratory ResearchLeadLearningMedical centerMedicineMethodsMinorityMonitorNamesOrganOrganismOutcomePathogenesisPatientsPediatric HospitalsPhasePhenotypePluripotent Stem CellsPopulationPositioning AttributeRaceRegistriesReportingResearchResearch DesignResearch PersonnelSample SizeSamplingSecurityServicesSex DistributionStatistical Data InterpretationStomachTechnologyTherapeutic InterventionTissuesTrainingTranslational ResearchTranslationsUniversitiesWorkadvanced analyticsbasebench to bedsidebiobankclinical careclinical centerclinically actionableclinically significantcollegedata infrastructuredata managementdesigndiagnostic strategydisease registryeffective therapyhuman diseasehuman tissueinnovationlarge datasetsnovel therapeuticsorgan injurypre-clinicalpreclinical studyrepositoryresponsetoolweb portal
中文摘要
项目摘要
消化健康中心(DHC)临床部分的总体目标是加速
将基础研究转化为儿科消化系统疾病的临床研究和试验。临床
组件通过三个互补的目标来实现这一目标。在第一个目标中,“为研究提供咨询
为DHC研究者提供设计和生物统计服务,”临床部分为DHC提供
研究者可以使用基于网络的门户网站,提供与研究设计、统计分析和结果报告相关的服务。
该服务线由临床部分总监和一名生物统计学家领导,该生物统计学家具有以下专业知识:
消化系统疾病研究。也可以通过辛辛那提中心获得补贴咨询,
转化科学和培训以及机构数据管理和分析中心(DMAC),
工作人员为统计学家和经认证的数据分析师。第二个目标是“提供数据管理和
实施、监测和报告以患者为基础的消化系统疾病研究的基础设施,”
临床部分为DHC调查人员提供了获取综合数据的基础设施
通过DMAC、REDcap等大数据平台提供管理服务。这些平台依靠严格的
临床和转化研究的安全和合规性要求。在第三个目标中,“提供
获得消化系统疾病研究的组织和基因组样本,”临床组件与
机构生物库,旨在促进儿科人群中基于患者的研究。的
生物库使DHC研究人员能够获得去识别的储存组织和相关疾病
已批准研究的信息。它还促进了定制生物储存库的开发,
制药商发起的项目,并帮助提交IRB的建议,重点是消化系统的研究
疾病生物统计学和研究设计咨询是试点项目审查和排名的关键组成部分
和可行性项目,以确保申请人在设计预
临床和临床研究。在本供资期内,临床部分支持了30多个地区保健中心,
研究人员进行了12,119小时的统计分析,10,775小时的REDCap使用和支持,以及
从消化系统疾病器官获取1,184个组织。我们有能力继续满足
DHC调查员,将我们的服务与其他DHC核心整合,并加快基本的
研究儿科消化系统疾病的临床研究和试验。
英文摘要
PROJECT SUMMARY
The overall goal of the Clinical Component of the Digestive Health Center (DHC) is to accelerate the
translation of basic research into clinical studies and trials for pediatric digestive diseases. The Clinical
Component pursues this goal with three complementary aims. In the first Aim “to provide consultation on study
design and biostatistical services for DHC investigators,” the Clinical Component makes available to DHC
investigators a web-based portal for services related to study design, statistical analysis, and result reporting.
This line of services is led by the Director of the Clinical Component and a biostatistician with expertise on
digestive disease studies. Subsidized consultation is also available through the Cincinnati Center for
Translational Science and Training and institutional Data Management and Analysis Center (DMAC), which are
staffed by statisticians and certified data analysts. In the second Aim “to provide data management and
infrastructure for implementation, monitoring, and reporting of patient-based research on digestive diseases,”
the Clinical Component makes available to DHC investigators the infrastructure for comprehensive data
management services via DMAC, REDcap and other large-data platforms. These platforms count on rigorous
security and compliance requirements for clinical and translational research. And in the third Aim “to provide
access to tissues and genomic samples for digestive disease research,” the Clinical Component partners with
the institutional biobank that is designed to facilitate patient-based research in the pediatric population. The
biobank makes it possible for DHC investigators to obtain de-identified stored tissues and relevant disease
information for approved studies. It also facilitates the development of customized biorepositories for
investigator-initiated projects and helps with submission of IRB proposals focused on studies of digestive
diseases. Biostatistical and study design consultations are a key component of the review and ranking of Pilot
and Feasibility projects to ensure that applicants use scientifically rigorous approaches when designing pre-
clinical and clinical studies. In the current funding period, the Clinical Component supported over 30 DHC
Investigators with 12,119 hours of statistical analysis, 10,775 hours of REDCap usage and support, and
access to 1,184 tissues from digestive disease organs. We are well positioned to continue to serve the needs
of DHC Investigators, integrate our services with other DHC Cores, and accelerate the translation of basic
research into clinical studies and trials for pediatric digestive diseases.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Bone Mineral Accretion in Young Children
-
批准号:8741982
-
项目类别:
-
资助金额:$104.01万
-
财政年份:2013
-
负责人:Heidi J Kalkwarf
-
依托单位:
Bone Mineral Accretion in Young Children
-
批准号:8914657
-
项目类别:
-
资助金额:$103.05万
-
财政年份:2013
-
负责人:Heidi J Kalkwarf
-
依托单位:
Bone Mineral Accretion in Young Children
-
批准号:8631290
-
项目类别:
-
资助金额:$100.88万
-
财政年份:2013
-
负责人:Heidi J Kalkwarf
-
依托单位:
EFFECTS OF RENAL OSTEODYSTROPHY DURING GROWTH
-
批准号:7607736
-
项目类别:
-
资助金额:$1.84万
-
财政年份:2007
-
负责人:Heidi J Kalkwarf
-
依托单位:
BONE MINERAL DENSITY IN CHILDHOOD STUDY
-
批准号:7607733
-
项目类别:
-
资助金额:$17.66万
-
财政年份:2007
-
负责人:Heidi J Kalkwarf
-
依托单位:
Clinical-Component
-
批准号:10620723
-
项目类别:
-
资助金额:$5.92万
-
财政年份:2007
-
负责人:Heidi J Kalkwarf
-
依托单位:
Clinical Component
-
批准号:9312951
-
项目类别:
-
资助金额:$5.73万
-
财政年份:2007
-
负责人:Heidi J Kalkwarf
-
依托单位:
REFERENCE VALUES FOR BONE MASS AND DENSITY OF LUMBAR SPINE
-
批准号:7607800
-
项目类别:
-
资助金额:$2.62万
-
财政年份:2007
-
负责人:Heidi J Kalkwarf
-
依托单位:
EFFECTS OF RENAL OSTEODYSTROPHY DURING GROWTH
-
批准号:7374508
-
项目类别:
-
资助金额:$5.08万
-
财政年份:2005
-
负责人:Heidi J Kalkwarf
-
依托单位:
BONE MINERAL DENSITY IN CHILDHOOD STUDY
-
批准号:7374504
-
项目类别:
-
资助金额:$18.43万
-
财政年份:2005
-
负责人:Heidi J Kalkwarf
-
依托单位:
BONE MINERAL DENSITY IN CHILDHOOD STUDY
-
批准号:7203752
-
项目类别:
-
资助金额:$16.83万
-
财政年份:2004
-
负责人:Heidi J Kalkwarf
-
依托单位:
EFFECTS OF RENAL OSTEODYSTROPHY DURING GROWTH
-
批准号:7203758
-
项目类别:
-
资助金额:$5.95万
-
财政年份:2004
-
负责人:Heidi J Kalkwarf
-
依托单位:
Bone Mineral Density in Childhood Study
-
批准号:7044191
-
项目类别:
-
资助金额:$20.05万
-
财政年份:2003
-
负责人:Heidi J Kalkwarf
-
依托单位:
Effects of Renal Osteodystrophy During Growth
-
批准号:7044198
-
项目类别:
-
资助金额:$5.12万
-
财政年份:2003
-
负责人:Heidi J Kalkwarf
-
依托单位:
Bone Density and Forearm Fractures
-
批准号:7044168
-
项目类别:
-
资助金额:$6.17万
-
财政年份:2003
-
负责人:Heidi J Kalkwarf
-
依托单位:
BONE MINERAL DENSITY IN CHILDHOOD STUDY-CLINICAL CENTER
-
批准号:7542777
-
项目类别:
-
资助金额:$55.86万
-
财政年份:2001
-
负责人:Heidi J Kalkwarf
-
依托单位:--
BONE DENSITY AND FOREARM FRACTURES IN INJURED CHILDREN
-
批准号:6375370
-
项目类别:
-
资助金额:$25.12万
-
财政年份:2000
-
负责人:Heidi J Kalkwarf
-
依托单位:
TRACKING OF BONE MASS DURING CHILDHOOD AND ADOLESCENCE
-
批准号:6414961
-
项目类别:
-
资助金额:$2.85万
-
财政年份:2000
-
负责人:Heidi J Kalkwarf
-
依托单位:
BONE DENSITY AND FOREARM FRACTURES IN INJURED CHILDREN
-
批准号:6534515
-
项目类别:
-
资助金额:$21.53万
-
财政年份:2000
-
负责人:Heidi J Kalkwarf
-
依托单位:
BONE DENSITY AND FOREARM FRACTURES IN INJURED CHILDREN
-
批准号:6196529
-
项目类别:
-
资助金额:$25.12万
-
财政年份:2000
-
负责人:Heidi J Kalkwarf
-
依托单位:
国内基金
海外基金
登录
查看更多内容
补阳还五汤通过AGE-RAGE通路调控脓毒症免疫失衡的机制与转化研究
-
批准号:JCZRLH202601523
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2026
-
负责人:
-
依托单位:
靶向递送一氧化碳调控AGE-RAGE级联反应促进糖尿病创面愈合研究
-
批准号:JCZRQN202500010
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2025
-
负责人:
-
依托单位:
对香豆酸抑制AGE-RAGE-Ang-1通路改善海马血管生成障碍发挥抗阿尔兹海默病作用
-
批准号:2025JJ70209
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2025
-
负责人:雷芬芳
-
依托单位:
AGE-RAGE通路调控慢性胰腺炎纤维化进程的作用及分子机制
-
批准号:--
-
项目类别:面上项目
-
资助金额:--
-
批准年份:2024
-
负责人:万荣
-
依托单位:
甜茶抑制AGE-RAGE通路增强突触可塑性改善小鼠抑郁样行为
-
批准号:2023JJ50274
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2023
-
负责人:贺志明
-
依托单位:
蒙药额尔敦-乌日勒基础方调控AGE-RAGE信号通路改善术后认知功能障碍研究
-
批准号:--
-
项目类别:地区科学基金项目
-
资助金额:33万元
-
批准年份:2022
-
负责人:都义日
-
依托单位:
补肾健脾祛瘀方调控AGE/RAGE信号通路在再生障碍性贫血骨髓间充质干细胞功能受损的作用与机制研究
-
批准号:--
-
项目类别:面上项目
-
资助金额:52万元
-
批准年份:2022
-
负责人:叶宝东
-
依托单位:
LncRNA GAS5在2型糖尿病动脉粥样硬化中对AGE-RAGE 信号通路上相关基因的调控作用及机制研究
-
批准号:
-
项目类别:省市级项目
-
资助金额:10.0万元
-
批准年份:2022
-
负责人:于海兵
-
依托单位:
围绕GLP1-Arginine-AGE/RAGE轴构建探针组学方法探索大柴胡汤异病同治的效应机制
-
批准号:81973577
-
项目类别:面上项目
-
资助金额:55.0万元
-
批准年份:2019
-
负责人:辛贵忠
-
依托单位:
AGE/RAGE通路microRNA编码基因多态性与2型糖尿病并发冠心病的关联研究
-
批准号:81602908
-
项目类别:青年科学基金项目
-
资助金额:18.0万元
-
批准年份:2016
-
负责人:刘括
-
依托单位: