Bone Mineral Accretion in Young Children
幼儿骨矿物质沉积
基本信息
- 批准号:8741982
- 负责人:
- 金额:$ 104.01万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-09-30 至 2018-07-31
- 项目状态:已结题
- 来源:
- 关键词:5 year oldAccountingAddressAffectAgeBody CompositionBone DensityBone DevelopmentBone GrowthBone Mineral ContentsCancer SurvivorCaringCharacteristicsChildChild CareChildhoodChronicChronic DiseaseClinicalClinical TreatmentClinical assessmentsCollaborationsCrohn&aposs diseaseDataDevelopmentDietary intakeDiseaseDual-Energy X-Ray AbsorptiometryFemaleFractureGastrointestinal DiseasesGlareGlucocorticoidsGoalsGrowthHealthHealth Care CostsHealth StatusInterdisciplinary StudyKidney DiseasesKnowledgeLengthLocomotionLongitudinal StudiesMeasurementMeasuresMechanicsMedicalMethodsMineralsMissionMonitorMorbidity - disease rateMotorMotor SkillsMusculoskeletal DiseasesNeuromuscular DiseasesOsteoporosisOutcomePatternPersonal SatisfactionPhysical activityPredispositionPublic HealthRaceRecording of previous eventsResearchRiskRisk FactorsScanningSiteSkeletonSleepStagingTechniquesTestingTimeTissuesWalkingWeightage groupbonebone healthbone strengthcalcium intakeclinical applicationclinically relevantdensityearly childhoodimprovedinfancymalenovelprematurepreventpublic health relevancerapid growthresponserestricted physical activitysexskeletal
项目摘要
DESCRIPTION (provided by applicant): Children with chronic medical conditions are at risk of compromised bone strength and increased fracture susceptibility. Recently developed reference data have enabled clinicians to identify children 5 to 20 y with compromised bone mineral status (low bone density for age) and optimize their medical care. A glaring deficit is the inability to evaluate bone health of young children < 5 y due to lack of appropriate bone density reference data, although numerous clinical conditions (e.g., prematurity, gastrointestinal and neuromuscular disorders) threaten bone health in this young age range. Early childhood differs from other developmental stages. In older children, the need to account for growth status and lean mass when interpreting bone measurements has been demonstrated, but in early childhood, these effects are unknown. Pronounced changes in gross motor skills, locomotion and physical activity also occur in early childhood. Mechanical loads on the growing skeleton promote bone mineral accrual. Understanding the impact of growth, body composition, motor skill development, and physical activity on bone accrual in young children is critical for interpretation of a clinical bone mineral status measurement. These characteristics are often affected in young children with chronic medical conditions. The long-term goal of this study is to
optimize bone health of young children. The objectives of this longitudinal study are to develop regional and total body bone mineral content (BMC) and density (aBMD) reference data for children ages 1-5 y to aid identification of young children with bone deficits, and identify factor that influence bone accrual in this age group. The aims of this longitudinal study are: (1) test fo sex and ancestry differences in BMC and aBMD at multiple skeletal sites in healthy children ages 1 to 5 y, and create appropriate reference curves; (2) assess the influence of growth and body composition, and (3) gross motor skills and physical activity on bone mineral status and bone mineral accrual, and (4) determine the degree of "tracking" of bone status in young children. Hypotheses to be tested are: males will have greater BMC and aBMD than females; Blacks will have greater BMC and aBMD than non-blacks; bone mineral status and bone accrual will be greater in children with greater growth status and more lean tissue, more advanced gross motor skills, and higher physical activity levels; and BMC and aBMD z-scores will be positively correlated over 3 y. The study is unique since no previous studies have addressed these issues in children 1-5 y. It is clinically relevant as findings will facilitate medcal care of children with chronic medical conditions that threaten bone health, and it will develop and validate novel methods for bone and body composition assessment in this age range. It will also add generalizable knowledge to enhance understanding of the growing skeleton, and its relationship to motor and somatic development. Since poor bone mineral accrual can have lifelong consequences, this study addresses the major public health concern of osteoporosis.
描述(由申请人提供):患有慢性疾病的儿童有骨强度受损和骨折易感性增加的风险。最近开发的参考数据使临床医生能够识别5至20岁的儿童骨矿物质状态受损(年龄骨密度低),并优化他们的医疗护理。一个明显的缺陷是由于缺乏适当的骨密度参考数据而无法评估< 5岁幼儿的骨健康,尽管许多临床条件(例如,早产、胃肠道和神经肌肉疾病)威胁着这个年轻年龄段的骨骼健康。 幼儿期不同于其他发育阶段。在年龄较大的儿童中,在解释骨骼测量时需要考虑生长状态和瘦体重,但在幼儿期,这些影响尚不清楚。在幼儿期,粗大运动技能、运动和身体活动也发生显著变化。生长骨骼上的机械负荷促进骨矿物质积累。了解生长、身体成分、运动技能发展和体力活动对幼儿骨增长的影响对于解释临床骨矿物质状态测量至关重要。这些特征往往在患有慢性疾病的幼儿中受到影响。 这项研究的长期目标是
优化幼儿的骨骼健康。这项纵向研究的目的是为1-5岁儿童制定区域和全身骨矿物质含量(BMC)和密度(aBMD)参考数据,以帮助识别骨缺损的幼儿,并确定影响该年龄组骨增长的因素。本纵向研究的目的是:(1)检验1 ~ 5岁健康儿童多个骨骼部位BMC和aBMD的性别和血统差异,并建立适当的参考曲线;(2)评估生长和身体组成的影响,和(3)粗大运动技能和体力活动对骨矿物质状态和骨矿物质积累的影响,和(4)确定幼儿骨骼状态的“跟踪”程度。待检验的假设为:男性的BMC和aBMD比女性高;黑人的BMC和aBMD比非黑人高;生长状态更好、瘦肉组织更多、粗大运动技能更先进、体力活动水平更高的儿童的骨矿物质状态和骨累积更高; BMC和aBMD z-评分在3年内呈正相关。这项研究是独一无二的,因为以前没有研究解决这些问题的儿童1-5岁。它具有临床意义,因为研究结果将促进对患有威胁骨骼健康的慢性疾病的儿童的医疗护理,并且它将开发和验证用于该年龄段骨骼和身体成分评估的新方法。它还将增加可推广的知识,以加强对骨骼生长及其与运动和躯体发育的关系的理解。由于骨矿物质积累不良可能会产生终身后果,因此本研究解决了骨质疏松症的主要公共卫生问题。
项目成果
期刊论文数量(0)
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Heidi J Kalkwarf其他文献
Heidi J Kalkwarf的其他文献
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{{ truncateString('Heidi J Kalkwarf', 18)}}的其他基金
EFFECTS OF RENAL OSTEODYSTROPHY DURING GROWTH
肾性骨营养不良对生长过程的影响
- 批准号:
7607736 - 财政年份:2007
- 资助金额:
$ 104.01万 - 项目类别:
REFERENCE VALUES FOR BONE MASS AND DENSITY OF LUMBAR SPINE
腰椎骨量和密度参考值
- 批准号:
7607800 - 财政年份:2007
- 资助金额:
$ 104.01万 - 项目类别:
EFFECTS OF RENAL OSTEODYSTROPHY DURING GROWTH
肾性骨营养不良对生长过程的影响
- 批准号:
7374508 - 财政年份:2005
- 资助金额:
$ 104.01万 - 项目类别:
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