ENDOCRINOPATHIES AFTER HEAD INJURY

头部受伤后的内分泌疾病

• 批准号: 7607737
• 负责人: SUSAN A ROSE
• 金额: $ 1.39万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-15 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607737
• 关键词: Child; Childhood Injury; Classification; Computer Retrieval of Information on Scientific Projects Database; Craniocerebral Trauma; Development, Other; Endocrine; Evaluation; Frequencies; Functional disorder; Funding; Grant; Growth; Hydrocortisone; Hypothalamic structure; Injury; Institution; Measurement; Pattern; Pituitary Gland; Prolactin; Rate; Reporting; Research; Research Personnel; Resources; Risk; Screening procedure; Serum; Somatotropin; Source; Symptoms; Testing; Thyroid Gland; Thyrotropin; Time; United States National Institutes of Health; prospective

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Children with endocrinopathies resulting from head injury may not present with symptoms for several years after the injury. No prospective trial has been reported assessing the frequency of endocrinopathy after head injury in children. We hypothesize that systematic endocrine evaluation six months after the injury will identify those children at risk for developing later endocrinopathy. Specifically, we hypothesize that an abnormal pattern of thyrotropin (TSH) or growth hormone (GH) secretion, or an elevated serum prolactin concentration, will predict development of other hypothalamic-pituitary dysfunctions. In the current study, 40 children who have survived significant head injury will have baseline thyroid, cortisol, growth hormone screen, and prolactin measurement at the time of injury and 2 to 3 months later. They will then undergo study of their pattern of overnight TSH and GH secretion at 6 months after injury. Subsequently, their growth rate and endocrine screening tests will be evaluated at one year after injury.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 受伤后几年，由于头部受伤引起的内分泌病的儿童可能不会出现症状。 尚无预期试验评估儿童头部受伤后内分泌病的频率。 我们假设受伤六个月后系统的内分泌评估将确定那些有患后晚分泌病风险的儿童。 具体而言，我们假设甲状腺激素（TSH）或生长激素（GH）分泌或血清催乳素浓度升高的异常模式将预测其他下丘脑诊断性功能障碍的发展。 在当前的研究中，有40名在重大损伤中幸存下来的儿童将有甲状腺基线，皮质醇，生长激素筛查和催乳素在受伤时和2至3个月后的测量。 然后，他们将在受伤后6个月后研究其通宵TSH和GH分泌的模式。 随后，他们的生长速率和内分泌筛查测试将在受伤后一年进行评估。