THYROID HORMONE IN CHILDREN WITH FANCONI ANEMIA

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本研究的目的是了解范可尼贫血患儿在接受甲状腺药物治疗后是否会长高。患有范可尼贫血症的儿童通常比其他同龄儿童矮，不能长到正常身高。这可能是由于体内甲状腺激素水平低。这种药能提高体内甲状腺激素水平。甲状腺是人体内正常产生的化学信使，是长高所必需的。这项研究的第二个目的是找出甲状腺激素对血液计数的影响（好或坏）。每个儿童将随机接受治疗或安慰剂，每个治疗期共7个月。每个孩子将在研究中总共14个月。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this research study is to find out whether children with Fanconi anemia will grow taller when treated with thyroid medicine. Children with Fanconi anemia are often shorter than other children their age and do not grow to normal height. This may be due low levels of thyroid hormone in the body. This medicine raises thyroid hormone levels in the body. Thyroid is a normally occurring chemical messenger in the body that is needed to grow taller. The second purpose of this study is to find out what effect (good or bad) thyroid hormone has on blood counts. Each child will be randomized to receive either treatment or placebo first for a total of 7 months in each treatment period. Each child will be in the study for a total of 14 months.