THYROID HORMONE IN CHILDREN WITH FANCONI ANEMIA

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项研究的目的是为了找出范可尼贫血的儿童在接受甲状腺药物治疗后是否会长得更高。患有Fanconi贫血的儿童通常比其他同龄儿童矮，无法长到正常身高。这可能是由于体内甲状腺激素水平较低所致。这种药会提高体内的甲状腺激素水平。甲状腺是体内一种正常存在的化学信使，需要长得更高。这项研究的第二个目的是找出甲状腺激素对血细胞计数有什么影响(好的或坏的)。每个儿童将随机接受治疗或安慰剂，在每个治疗期总共7个月。每个孩子将在这项研究中总共呆上14个月。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this research study is to find out whether children with Fanconi anemia will grow taller when treated with thyroid medicine. Children with Fanconi anemia are often shorter than other children their age and do not grow to normal height. This may be due low levels of thyroid hormone in the body. This medicine raises thyroid hormone levels in the body. Thyroid is a normally occurring chemical messenger in the body that is needed to grow taller. The second purpose of this study is to find out what effect (good or bad) thyroid hormone has on blood counts. Each child will be randomized to receive either treatment or placebo first for a total of 7 months in each treatment period. Each child will be in the study for a total of 14 months.