ADOLESCENT GASTRIC BYPASS AND DIABETIC PRECURSORS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该项目将开始详细研究胰岛素抵抗、β细胞功能、人体测量学、营养和体力活动在病态肥胖成人与接受减肥手术的青少年中与碳水化合物代谢的关系。虽然众所周知，胃旁路手术会导致纠正某些代谢问题所需的体重减轻，但对于何时需要发生这些变化以提供最佳长期结果知之甚少。有证据表明，如果长期不治疗，胰腺可能会“烧坏”，然后代谢问题可能不会完全逆转。将比较胃旁路术对成人和青少年代谢的影响，以确定在生命早期进行胃旁路术与等到成年后进行胃旁路术是否具有更大的代谢和健康优势。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project will begin a detailed study of insulin resistance, beta cell function, anthropometrics, nutrition, and physical activity in morbidly obese adults compared to adolescents undergoing bariatric surgery in relation to carbohydrate metabolism. While it is known that gastric bypass causes the weight loss necessary to correct some metabolism problems, not much is known about when these changes need to happen to provide the best long term outcome. Evidence suggests that if left untreated for too long the pancreas can "burn out" and then the metabolism problems may be less completely reversed. The effects of gastric bypass on the metabolism of adults and adolescents will be compared to try to determine whether there are greater metabolic and health advantages of performing gastric bypass earlier in life versus waiting until adulthood.