COLLECTION AND BANKING OF BIOLOGICAL SPECIMENS

生物样本的采集和储存

• 批准号: 7607773
• 负责人: THOMAS HARRIS INGE
• 金额: $ 0.39万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-15 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607773
• 关键词: Bariatrics; Biochemical; Biological; Biological Specimen Banks; Blood; Body Weight decreased; Childhood; Collection; Computer Retrieval of Information on Scientific Projects Database; Development; Disease; Fatty acid glycerol esters; Funding; Grant; Health Benefit; Human; Individual; Institution; Invasive; Laboratories; Lead; Learning; Liver; Medical History; Obesity; Operative Surgical Procedures; Pathway interactions; Patients; Primitive foregut structure; Procedures; Protocols documentation; Purpose; Research; Research Personnel; Resources; Sampling; Source; Specimen; Tissues; United States National Institutes of Health; bariatric surgery; energy balance; gastrointestinal; repository; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this research protocol is to help researchers learn more about pediatric obesity. Blood, fat, gastrointestinal tissue and liver tissue collected from this unique group of patients who are undergoing bariatric surgery may harbor clues to the pathophysiologic mechanisms that lead to extreme pediatric obesity and the mechanisms by which massive weight loss benefits the health of these individuals. The mechanism by which this occurs is unclear, but likely involves fundamental alterations in the endocrinologic function of the human foregut as well as energy balance pathways. A detailed understanding of the mechanisms by which bariatric surgical therapy produces such dramatic morphologic and biochemical changes can be explored for the potential development of alternative treatment paradigms that do not require invasive, risky procedures. This protocol allows for the acquisition of key samples to create a long-term repository of biological specimens from patients both before and after surgery. In addition, past medical history, demographic, anthropometric, surgical, and laboratory information is collected to permit selection of specimens to be used in hypothesis-driven research studies of obesity and related disorders.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该研究方案的目的是帮助研究人员更多地了解儿童肥胖。从这一接受减肥手术的独特患者群体中收集的血液、脂肪、胃肠道组织和肝脏组织可能为导致儿童极度肥胖的病理生理机制以及大规模减肥有益于这些个体的健康的机制提供线索。这种情况发生的机制尚不清楚，但可能涉及人类前肠内分泌功能以及能量平衡途径的根本改变。详细了解减肥手术治疗产生如此剧烈的形态和生化变化的机制，可以探索潜在的开发替代治疗范例，不需要侵入性、危险的手术。该协议允许采集关键样本，以创建手术前后患者生物样本的长期存储库。此外，还收集过去的病史、人口统计、人体测量、手术和实验室信息，以便选择用于肥胖和相关疾病的假设驱动研究的样本。