COLLECTION AND BANKING OF BIOLOGICAL SPECIMENS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究方案的目的是帮助研究人员更多地了解儿童肥胖。从这组正在接受减肥手术的独特患者身上收集的血液、脂肪、胃肠道组织和肝组织可能包含导致儿童极端肥胖的病理生理机制的线索，以及大规模减肥有益于这些人健康的机制。发生这种情况的机制尚不清楚，但可能涉及人类前庭内分泌功能以及能量平衡途径的根本性变化。对减肥手术治疗产生如此显著的形态和生化变化的机制的详细了解可以被探索为潜在的开发不需要侵入性的、有风险的程序的替代治疗范例。这项协议允许获取关键样本，以创建手术前和手术后患者生物样本的长期储存库。此外，还收集了过去的病史、人口统计学、人体测量学、外科手术和实验室信息，以便选择样本用于肥胖症和相关疾病的假说驱动研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this research protocol is to help researchers learn more about pediatric obesity. Blood, fat, gastrointestinal tissue and liver tissue collected from this unique group of patients who are undergoing bariatric surgery may harbor clues to the pathophysiologic mechanisms that lead to extreme pediatric obesity and the mechanisms by which massive weight loss benefits the health of these individuals. The mechanism by which this occurs is unclear, but likely involves fundamental alterations in the endocrinologic function of the human foregut as well as energy balance pathways. A detailed understanding of the mechanisms by which bariatric surgical therapy produces such dramatic morphologic and biochemical changes can be explored for the potential development of alternative treatment paradigms that do not require invasive, risky procedures. This protocol allows for the acquisition of key samples to create a long-term repository of biological specimens from patients both before and after surgery. In addition, past medical history, demographic, anthropometric, surgical, and laboratory information is collected to permit selection of specimens to be used in hypothesis-driven research studies of obesity and related disorders.