COLLECTION AND BANKING OF BIOLOGICAL SPECIMENS

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this research protocol is to help researchers learn more about pediatric obesity. Blood, fat, gastrointestinal tissue and liver tissue collected from this unique group of patients who are undergoing bariatric surgery may harbor clues to the pathophysiologic mechanisms that lead to extreme pediatric obesity and the mechanisms by which massive weight loss benefits the health of these individuals. The mechanism by which this occurs is unclear, but likely involves fundamental alterations in the endocrinologic function of the human foregut as well as energy balance pathways. A detailed understanding of the mechanisms by which bariatric surgical therapy produces such dramatic morphologic and biochemical changes can be explored for the potential development of alternative treatment paradigms that do not require invasive, risky procedures. This protocol allows for the acquisition of key samples to create a long-term repository of biological specimens from patients both before and after surgery. In addition, past medical history, demographic, anthropometric, surgical, and laboratory information is collected to permit selection of specimens to be used in hypothesis-driven research studies of obesity and related disorders.