Teen Longitudinal Assessment of Bariatric Surgery (Teen LABS) Research Project

摘要 本申请要求续签目前支持以下五个临床中心的拨款 组成Teen-Labs(TL)联盟。这项多中心、前瞻性、观察性研究 减肥手术的风险和益处成功招募了242名青少年 在参与的临床中心接受减肥手术，并将这些受试者保留了 长期随访。到本供资期间结束时(2016年8月)，大多数国家将 完成5年随访。资金的更新将提供一个机会来研究长期- 最常用的Roux-en-Y胃分流术和袖状胃切除术的远期疗效 今天的行动。从第6年到第10年收集额外的纵向措施将非常重要 记录体重减轻和合并症解决的持久性、生活质量、微量营养素状况、 并将确定长期的不良事件。继续收集生物制品将继续 利用辅助研究机制推动调查人员的新发现。添加新的 研究骨骼健康、认知功能和行为模式的措施将进一步增强 研究延伸的价值所在。

Abstract This application requests renewal of the current grant supporting the five clinical centers that comprise the Teen-LABS (TL) consortium. This multicenter, prospective, observational study of the risks and benefits bariatric surgery successfully recruited 242 consecutive adolescents undergoing bariatric surgery at participating clinical centers and has retained these subjects for long-term follow up. By the end of the current funding period (August 2016), most will have completed 5 years of follow-up. A renewal of funding will provide an opportunity to examine long- term outcomes of Roux en Y gastric bypass and sleeve gastrectomy, the most commonly used operations today. Collection of additional longitudinal measures from years 6 to10 will importantly document durability of weight loss and comorbidity resolution, quality of life, micronutrient status, and will identify long-term adverse events. Continued collection of biospecimens will continue to drive new discovery by investigators utilizing the ancillary studies mechanism. Addition of new measures to study bone health, cognitive function, and behavioral patterns will further enhance the value of an extension of the study.