Teen Longitudinal Assessment of Bariatric Surgery (Teen LABS) Research Project

青少年减肥手术纵向评估（青少年实验室）研究项目

• 批准号: 9763597
• 负责人: THOMAS HARRIS INGE
• 金额: $ 115.05万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-23 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9763597
• 关键词: Abdomen; Adolescence; Adolescent; Adult; Adverse event; Affect; Alcohol abuse; Alcohols; Ancillary Study; Bariatrics; Behavior; Behavioral; Benefits and Risks; Blood Pressure; Body Weight decreased; Bone Density; Cardiovascular system; Cessation of life; Child; Childbirth; Clinical; Collection; Comorbidity; Data; Disease remission; Documentation; Eating Behavior; Enrollment; Folic Acid; Functional disorder; Funding; Future; Gastrectomy; Gastric Bypass; Grant; Health; High Density Lipoprotein Cholesterol; Hospitalization; Impaired cognition; Impairment; Individual; Late Effects; Longterm Follow-up; Measures; Micronutrients; Morbid Obesity; Neck; Obesity; Observational Study; Operative Surgical Procedures; Outcome; Participant; Pattern; Pregnancy; Procedures; Quality of life; Regulation; Relapse; Request for Applications; Research Personnel; Research Project Grants; Resolution; Risk; Risk-Taking; Safety; Surgical complication; Teenagers; Time; Transferrin; Triglycerides; Visit; Vitamin D; Weight; adverse outcome; bariatric surgery; base; behavioral construct; bone health; cardiovascular risk factor; cognitive control; cognitive function; comparative effectiveness; depressive symptoms; experience; follow-up; loss of control over eating; obesity in children; operation; prospective; recruit; reward processing; treatment effect

Abstract This application requests renewal of the current grant supporting the five clinical centers that comprise the Teen-LABS (TL) consortium. This multicenter, prospective, observational study of the risks and benefits bariatric surgery successfully recruited 242 consecutive adolescents undergoing bariatric surgery at participating clinical centers and has retained these subjects for long-term follow up. By the end of the current funding period (August 2016), most will have completed 5 years of follow-up. A renewal of funding will provide an opportunity to examine long- term outcomes of Roux en Y gastric bypass and sleeve gastrectomy, the most commonly used operations today. Collection of additional longitudinal measures from years 6 to10 will importantly document durability of weight loss and comorbidity resolution, quality of life, micronutrient status, and will identify long-term adverse events. Continued collection of biospecimens will continue to drive new discovery by investigators utilizing the ancillary studies mechanism. Addition of new measures to study bone health, cognitive function, and behavioral patterns will further enhance the value of an extension of the study.

摘要