Teen Longitudinal Assessment of Bariatric Surgery (Teen LABS) Research Project

青少年减肥手术纵向评估（青少年实验室）研究项目

• 批准号: 10570332
• 负责人: THOMAS HARRIS INGE
• 金额: $ 117.08万
• 依托单位: LURIE CHILDREN'S HOSPITAL OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-23 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10570332
• 关键词: Teen; Longitudinal; Assessment; Bariatric; Surgery

Abstract This application requests renewal of the current grant supporting the five clinical centers that comprise the Teen-LABS (TL) consortium. This multicenter, prospective, observational study of the risks and benefits bariatric surgery successfully recruited 242 consecutive adolescents undergoing bariatric surgery at participating clinical centers and has retained these subjects for long-term follow up. By the end of the current funding period (August 2016), most will have completed 5 years of follow-up. A renewal of funding will provide an opportunity to examine long- term outcomes of Roux en Y gastric bypass and sleeve gastrectomy, the most commonly used operations today. Collection of additional longitudinal measures from years 6 to10 will importantly document durability of weight loss and comorbidity resolution, quality of life, micronutrient status, and will identify long-term adverse events. Continued collection of biospecimens will continue to drive new discovery by investigators utilizing the ancillary studies mechanism. Addition of new measures to study bone health, cognitive function, and behavioral patterns will further enhance the value of an extension of the study.

摘要 本申请要求更新目前支持五个临床中心的拨款， Teen-LABS（TL）联盟。这项多中心、前瞻性、观察性研究， 减肥手术的风险和益处成功招募了242名连续的青少年 在参与的临床中心接受减肥手术，并保留这些受试者， 长期跟踪。到当前供资期结束时（2016年8月）， 完成5年随访。资金的更新将提供一个机会来审查长期的- Roux en Y胃旁路术和袖状胃切除术（最常用的 今天的行动。收集6至10年级的额外纵向测量数据， 记录体重减轻的持久性和并发症的解决，生活质量，微量营养素状况， 并将识别长期不良事件。将继续收集生物标本， 利用辅助研究机制推动研究者的新发现。增加新 研究骨骼健康、认知功能和行为模式的措施将进一步加强 扩大研究的价值。

项目成果

A Prospective Cohort of Alcohol Use and Alcohol-related Problems Before and After Metabolic and Bariatric Surgery in Adolescents.

青少年代谢和减肥手术前后饮酒和酒精相关问题的前瞻性队列。

• DOI: 10.1097/sla.0000000000005759
• 发表时间: 2023
• 期刊: Annals of surgery
• 影响因子: 9
• 作者: White,GretchenE;Boles,RichardE;Courcoulas,AnitaP;Yanovski,SusanZ;Zeller,MegH;Jenkins,ToddM;Inge,ThomasH
• 通讯作者: Inge,ThomasH