SYSTEMIC LUPUS ERYTHEMATOSUS IN GULLAH HEALTH (SLEIGH)

GULLAH HEALTH 中的系统性红斑狼疮（雪橇）

• 批准号: 7607141
• 负责人: DIANE L KAMEN
• 金额: $ 3.18万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607141
• 关键词: Affect; Africa; African American; Age; Area; Caucasians; Caucasoid Race; Cohort Studies; Computer Retrieval of Information on Scientific Projects Database; Development; Diagnostic tests; Disease; Environmental Exposure; Environmental Risk Factor; Family; Family member; Funding; Genes; Genetic; Grant; Health; Incidence; Institution; Island; Lead; Learning; Life; Lupus; Morbidity - disease rate; Oklahoma; Patients; Persons; Play; Population; Prevalence; Purpose; Rare Diseases; Research; Research Personnel; Resources; Sampling; Scientist; Sea; Socioeconomic Factors; Source; South Carolina; Systemic Lupus Erythematosus; USA Georgia; United States; United States National Institutes of Health; Western Asia Georgia; Work; body system; improved; mortality; socioeconomics

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The SLE in Gullah Health (SLEIGH) study is an observational cohort study of patients, their family members, and unrelated controls from the African American Gullah population living in the Sea Island areas of South Carolina and Georgia. The purpose of the SLEIGH study is to study both environmental and genetic contributions to SLE. The African American Gullah population is unique in its genetic homogeneity and stable family unit, making them a valuable cohort for the study of multigenic diseases such as SLE. Our central hypothesis in the SLEIGH study is that there are specific genetic factors that interact with environmental exposures leading to the development of SLE. African Americans have a three-fold increased incidence of SLE, develop SLE at an earlier age, and have increased SLE-related morbidity and mortality compared with Caucasians. It is likely that multiple factors, including genetic, environmental, and socioeconomic factors, underlie the ethnic disparity in SLE. Socioeconomic and genetic differences alone, however, cannot explain the significant increase in prevalence of SLE in the past 20 years or the gradient of SLE between West Africa where it is a rare disease, and the United States where it is prevalent. These latter findings suggest environmental factors are at play. The purpose of the study of Systemic Lupus Erythematosus (SLE) is to determine its cause, to improve understanding of it, and to help find new therapies. One very important part of this study is to help find the genes that cause lupus and to explain how they work. Learning what the genes are and how they work is expected to help lead toward advances that improve the diagnostic tests for lupus and the therapies for lupus. Lupus is a disease that may affect many different organ systems and how it affects people is often very different from person to person. Scientists will use samples and selected information from subjects to achieve this purpose. These scientists will be working both in Oklahoma and in other places.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 SLE在Gullah健康（SLEIGH）研究是一项观察性队列研究，研究对象为居住在南卡罗来纳州和格鲁吉亚海岛地区的非裔美国人Gullah人群的患者及其家庭成员和无关对照。SLEIGH研究的目的是研究环境和遗传对SLE的影响。 非裔美国人的Gullah人口是独特的，其遗传同质性和稳定的家庭单位，使他们成为一个有价值的队列研究多基因疾病，如SLE。我们在SLEIGH研究中的中心假设是，有特定的遗传因素与环境暴露相互作用，导致SLE的发展。 与白人相比，非裔美国人SLE的发病率增加3倍，发生SLE的年龄更早，SLE相关的发病率和死亡率增加。 多种因素，包括遗传、环境和社会经济因素，可能是SLE种族差异的基础。然而，社会经济和遗传差异本身并不能解释过去20年SLE患病率的显著增加，也不能解释西非和美国之间SLE的梯度，西非是一种罕见疾病，美国是一种流行病。这些发现表明环境因素在起作用。 系统性红斑狼疮（SLE）研究的目的是确定其病因，提高对其的理解，并帮助找到新的治疗方法。 这项研究的一个非常重要的部分是帮助找到导致狼疮的基因，并解释它们是如何工作的。 了解这些基因是什么以及它们是如何工作的，有望有助于改善狼疮的诊断测试和治疗方法。 狼疮是一种可能影响许多不同器官系统的疾病，它如何影响人们往往是因人而异的。 科学家们将使用样本和从受试者中选择的信息来实现这一目的。 这些科学家将在俄克拉荷马州和其他地方工作。