PHYSIOLOGIC RESPONSE TO INTERMITTENT CYCLIC HYPOXIA

这个子项目是众多研究子项目之一

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will examine how intermittent hypoxia alters hemodynamic, sympathetic, cognitive and metabolic function in normal volunteers exposed to cyclic hypoxia overnight for 28 nights. Exposure to intermittent hypoxia occurs as part of many disease states, including obstructive sleep apnea and may be associated with some environmental exposures. There is limited understanding of how exposure to intermittent hypoxia alters hemodynamic, sympathetic, cognitive, and metabolic function. The researchers hypothesize that intermittent cyclic hypoxia, which mimics the periodic desaturations that occur with obstructive sleep apnea, is associated with alterations in vascular tone, alertness and memory function, sympathetic activation, and glucose metabolism.