ADOLESCENT DEVELOPMENT STUDY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该项目采用了一种遗传高风险研究策略，以更好地了解精神病的易感性。它的主要目标是：确定青春期和年轻成年子女以及患有原发性精神障碍患者的兄弟姐妹的生理病理学和社会功能障碍的预测因子；表征精神障碍的神经发育底物，并确定神经退化是否与目前的精神病有关；建立一个基础设施，以监测处于痉挛遗传风险的青少年，以便未来的建议可以集中于早期干预方案。 这项研究旨在包括129名青少年和13-25岁的成年人，他们是精神病患者的子女或兄弟姐妹，因此具有精神病的遗传风险，以及161；低风险健康对照青少年和同龄的年轻人。所有青少年和青年受试者都将接受基线评估，其中包括神经心理、精神病倾向、心理社会和家庭功能测量。所有青少年和青年受试者也将在麻省理工学院接受结构和功能磁共振成像的评估。他们的父母或照顾者将通过表达情感和沟通偏差的测量进行评估。所有290名青少年和青年受试者及其良好的父母或照顾者将每隔六个月监测一次心理社会功能的临床显著变化。所有青少年和青年受试者都将被要求重复进行神经心理和结构/功能核磁共振检查，以进行为期两年的随访。鉴于精神病的发病年龄范围很广，因此将对所获得的样本进行多年跟踪调查。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project employes a genetic high-risk research strategy to better understand vulnerability to psychosis. Its key aims are to: (1) identify predictors of physchopathology and social dysfunction in adolescent and young adult offspring and siblings of patients with primary psychotic disorders; (2) charactherize the neurodevelopmental substrates of psychotic disorders and determine if neurodegeneration is associated with psychosis onsent; (3) establish an infrastructure to monitor adolescents at genetic risk for pyschosis so that future proposals can focus on early intervention protocols. This study aims to included 129 adolescents and younge adults (13-25 years of age) who are either offspring or siblings of patients with psychotic disorders and thus at genetic risk for psychosis and 161 "low risk" healthy control adolescents and young adults of the same ages. All adolescent and young adult subjects will receive a baseline assessment that includes neuropsychological, psychosis proneness, psychosocial and family functioning measures. All adolescent and young adult subjects will also be evaluated with structural and functional magnetic resonance imaging (MRI) at MGH. Their parents or caregivers will be assessed with measures of expressed emotion and communication deviance. All 290 adolescent and young adult subjects and their well paretn or caregiver will be monitored for clinically significant changes psychosocial functioning at six-month intervals. All adolescent and young adult subjects will be asked to repeat a neuropsychological and structural/functional MRI for a two-year follow-up. Given the wide age range for the onset of psychotic disorders, the obtained sample will be followed for many years.