SOCIAL, COGNITIVE DIFFICULTIES AND THOUGHT PROCESSES IN ADOLESCENTS/YOUNG ADULTS

青少年/年轻人的社交、认知困难和思维过程

• 批准号: 7606973
• 负责人: LARRY J SEIDMAN
• 金额: $ 0.23万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606973
• 关键词: Adolescent; Attenuated; Behavioral; Clinical; Cognitive; Computer Retrieval of Information on Scientific Projects Database; First Degree Relative; Functional disorder; Funding; Future; Genetic; Grant; Impairment; Individual; Institution; Knowledge; Longitudinal Studies; Measures; Monitor; Nature; Neurocognitive; Phase; Phenotype; Pre-study; Prevention; Process; Psychotic Disorders; Research; Research Infrastructure; Research Personnel; Resources; Risk; Risk Factors; Sampling; Schizophrenia; Socioeconomic Status; Source; Symptoms; Thinking; United States National Institutes of Health; experience; follow-up; healthy aging; sex; social; young adult

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a preliminary study aimed at advancing knowledge about the clinical phenomenology, neurocognitive profiles, and pathophysiology of schizophrenia through intensive study of the pre-psychotic, prodromal phase. The primary aims of this study are as follows: 1) to prospectively characterize the clinical, neurocognitive, social-behavioral, and neuroanatomical features of the early and late prodromal phases of schizophrenia. 2) To document the nature and degree of changes in clinical, neurocognitive and neuroanatomical status over the follow-up period. 3) To determine the nature of the relationship among risk factors, specifically between prodromal clinical impairment and neurocognitive functioning. 4) To compare these phenotypes to identical measures already collected on a sizeable sample of adolescents and young adults at genetic high-risk for schizophrenia (n=40) individuals with a first-degree relative suffering from schizophrenia and without attenuated schizophrenia-like symptoms and healthy, age, sex and parental socioeconomic status matched controls. 5) To develop a recruitment infrastructure for future large-scale, longitudinal treatment and prevention studies of the prodrome to schizophrenia. This is a longitudinal study that will monitor the symptoms and experiences of adolescent and young adult subjects who are considered to be clinically at-risk for developing psychosis.

这个子项目是众多研究子项目之一