ADOLESCENT/YOUNG ADULT SOCIAL, COGNITIVE DIFFICULTIES AND THOUGHT PROCESSES

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这是一项初步研究，旨在通过对精神病前期前驱期的深入研究，提高对精神分裂症的临床现象学、神经认知特征和病理生理学的认识。本研究的主要目的如下：1）前瞻性地描述精神分裂症前驱期早期和晚期的临床、神经认知、社会行为和神经解剖学特征。2)记录随访期间临床、神经认知和神经解剖状态变化的性质和程度。3)确定危险因素之间关系的性质，特别是前驱临床损害和神经认知功能之间的关系。4)将这些表型与已经收集到的相当大的精神分裂症遗传高风险青少年和年轻人样本（n=40）中的相同措施进行比较，这些个体具有一级亲属患有精神分裂症且没有减弱的精神分裂症样症状，健康，年龄，性别和父母社会经济地位匹配对照。5)为未来大规模的纵向治疗和预防精神分裂症前驱症状的研究建立招募基础设施。这是一项纵向研究，将监测被认为具有发生精神病临床风险的青少年和年轻成人受试者的症状和经历。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a preliminary study aimed at advancing knowledge about the clinical phenomenology, neurocognitive profiles, and pathophysiology of schizophrenia through intensive study of the pre-psychotic, prodromal phase. The primary aims of this study are as follows: 1) to prospectively characterize the clinical, neurocognitive, social-behavioral, and neuroanatomical features of the early and late prodromal phases of schizophrenia. 2) To document the nature and degree of changes in clinical, neurocognitive and neuroanatomical status over the follow-up period. 3) To determine the nature of the relationship among risk factors, specifically between prodromal clinical impairment and neurocognitive functioning. 4) To compare these phenotypes to identical measures already collected on a sizable sample of adolescents and young adults at genetic high-risk for schizophrenia (n=40) individuals with a first-degree relative suffering from schizophrenia and without attenuated schizophrenia-like symptoms and healthy, age, sex and parental socioeconomic status matched controls. 5) To develop a recruitment infrastructure for future large-scale, longitudinal treatment and prevention studies of the prodrome to schizophrenia. This is a longitudinal study that will monitor the symptoms and experiences of adolescent and young adult subjects who are considered to be clinically at-risk for developing psychosis.