ADVN BIOMARKER REGISTRY STUDY

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，但不一定是研究者所在的机构。 ADVN生物标志物登记研究的主要目的是促进ADVN临床研究，旨在降低EV（外排牛痘）的风险，EV是AD（特应性皮炎）受试者中发生的牛痘免疫并发症。具体而言，登记研究将为ADVN研究者提供一个充分表征的受试者池，该受试者池具有AD病史或当前活动性病例、存在其他疾病的AD和NA对照。此外，将要求受试者提供用于生物标志物评价的血液样本，并允许储存样本以支持未来分析。 ADVN生物标志物登记研究的主要目的是： “建立一个临床和诊断信息数据库，以及来自既往或当前患有AD伴既往或当前EH（外疱疹）、AD无EH（ADEH-）病史伴既往或当前EV、AD伴当前传染性软疣（MC）感染、非特应性MC感染和NA健康对照的受试者的生物样本。 本研究的次要目的是： “评估各种生物标志物与受试者特征之间的关系。目前的目标是使用生物标志物： - 表征AD受试者中Th 2极化的程度，并鉴定Th 2极化是否预测AD受试者对病毒感染（EH、EV或MC）的易感性。 - 确定准确表征AD临床严重程度的生物替代物，并评估疾病的严重程度是否是这些相同病毒并发症的预测因子。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary purpose of the ADVN Biomarker Registry Study is to facilitate ADVN clinical research designed to reduce the risk of EV (exzema vaccinatum), a complication of vaccinia immunization that occurs among subjects with AD (atopic dermatitis). Specifically, the Registry will provide ADVN investigators with access to a well-characterized subject pool with a history of or currently active cases of AD, AD with the presence of other conditions, and NA controls. In addition, subjects will be asked to provide a blood sample for evaluation of biomarkers and permission to store the samples to support future analysis. The primary objective of the ADVN Biomarker Registry Study is: " To establish a database of clinical and diagnostic information, and biological samples from subjects with previous or current AD with previous or current EH (exzema herpeticum), AD without a history of EH (ADEH-) AD with previous or current EV, AD with current molluscum contagiosum (MC) infection, nonatopic subjects with active MC infection, and NA healthy controls. The secondary objectives of this study are: " To assess the relationship between various biomarkers and subject characteristics. The current goals are to use biomarkers to: -Characterize the degree of Th2 polarization in AD subjects, and to identify whether Th2 polarization is predictive of susceptibility of AD subjects to viral infections (EH, EV, or MC). -Identify biological surrogates that accurately characterize the clinical severity of AD, and evaluate whether severity of disease is a predictor of these same viral complications.